Photodynamic therapy (PDT): The main principles and mechanism of action

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The effect of photodynamic therapy is based on local activation of the photosensitizer in the tissue by the infrared radiation that leads to photochemical reaction and tumor cells destruction. The clinical experience of using PDT demonstrates it’s efficacy. However, despite of 40-years history of this method, not all its benefits are researched

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Margarita Nikolayevna Slesarevskaya

St.-Petersburg State I. P. Pavlov Medical University

candidate of medical science, department of urology

Arkadiy Viktorovich Sokolov

St.-Petersburg State I. P. Pavlov Medical University



  1. Красновский А. А. Фотодинамическое действие и синглетный кислород // Биофизика. 2004. Т. 49. № 2. С. 305–321.
  2. Салмин Р. М. Основные направления фотодинамической терапии в медицине // Новости хирургии. 2008. № 3. С. 155–162.
  3. Странадко Е. Ф. Исторический очерк развития фотодинамической терапии // Лазер. мед. 2002. Т. 6. Вып. 1. С. 4–8.
  4. Толстых П. И., Клебанов Г. И., Шехтер А. Б. и др. Антиоксиданты и лазерное излучение в терапии ран и трофических язв. М.: ЭКО, 2002. С. 13.
  5. Якубовская Р. И., Немцова Е. Р. и др. Влияние фотодинамической терапии на состояние иммунной системы и антиоксидантного статуса у oнкологических больных // Рос. онкол. журн. 1997. № 2. С. 27–32.
  6. Agarwal R., Korman N. J., Mohan R. R. et al. Apoptosis is an early event during phthalocyanine photodynamic therapy-induced ablation of chemically induced squamous papillomas in mouse skin // J. Photochem Photobiol. 1996. Vol. 63. N 4. P. 547–552.
  7. Canti G., De Simone A., Korbelik M. Photodynamic therapy and the immune system in experimental oncology // J. Photochem. Photobiol. 2002. Vol. 1. P. 79–80.
  8. Courtice F. C. Lymph flow in the lunge // Brit. Med. Bull. 1963. Vol. 19. P. 76–79.
  9. Dougherty T. J., Kaufman J. E., Goldfarb A. et al. Photoradiation therapy for the treatment of malignant tumors // Cancer Res. 1978. Vol. 38. P. 2628–2635.
  10. Figge F. H. J., Weiland G. S., Manganiello L. O. Cancer detectionand therapy: affinity of neoplastic, embryonic, and traumatized tissues for porphyrins and metalloporphyrins // Proc. Soc. Exp. Biol. Med. 1948. Vol. 68. P. 181–188.
  11. Fingar V. H., Wieman T. J., Doak K. W. Role of thromboxane and prostacyclin release on photodynamic therapy induced tumor destruction // Cancer Res. 1990. — Vol. 50. P. 2599–2603.
  12. Freitas I. Lipid accumulation: the common feature to photosensitizer-retaining normal and malignant tissues [news] // J. Photochem. Photobiol. B. 1990. Vol. 7. P. 359–361.
  13. Gough M. J., Melcher A. A., Ahmed A. et al. Macrophages orchestrate the immune response to tumor cell death // Cancer Res. 2001. Vol. 61. P. 7240–7247.
  14. Henderson B. W., Fingar V. H. Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor // Cancer Res. 1987. Vol. 47. P. 3110–3114.
  15. Kelly J. F., Snell M. E. Hematoporphyrin derivative: a possible aid in the diagnosis and therapy of carcinoma of the bladder // J. Urol. 1976. Vol. 115. P. 150–151.
  16. Kerr J. F., Wyllie A. H., Currie A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics // Brit. J. Cancer. 1972. Vol. 26. P. 239–257.
  17. Lipson R. L., Baldes E. J., Olsen A. V. The use of a derivative hematoporhirin in tumor detection // J. Natl. Cancer Inst. 1961. Vol. 26. P. 1–8.
  18. McCaughan Jr. J. S. Photodynamic therapy // Drugs and Aging. 1999. Vol. 15(1). P. 49–68.
  19. Moan J., Pettersen E. O., Christensen T. The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin // Brit. J. Cancer. 1979. Vol. 39. P. 398–407.
  20. Moan J., Christensen T. Cellular uptake and photodynamic effect of hematoporphyrin // J. Photobiochem. Photobiophys. 1981. Vol. 2. P. 291–299.
  21. Moan J., McGhie J., Jacobsen P. B. Photodynamic effects on cells in vitro exposed to hematoporphyrin derivative and light // J. Photochem. Photobiol. 1983. Vol. 37. P. 599–04.
  22. Nieva J., Wentworth P. Jr. The antibody-catalyzed water oxidation pathway — a new chemical arm to immune defense? // Trends. Biochem. Sci. 2004. Vol. 29, N 5. P. 274–278.
  23. Oleinick N. L., Morris L., Varnes M. E. The peripheral benzodiazepine photosensitizer Pc4 // J. Photochem. and Photobiol. 2002. Vol.75(6). P. 652–661.
  24. Policard A. Etudes sur les aspects offerts par des tumeur experimentales examinee a la lumiere de woods // CR Soc Biol. 1924. Vol. 9. P.1423–1428.
  25. Raab O. Über die Wirkung fluorescierender Stoffe auf Infusorien // Biol. 1900. Vol. 39. P. 524–529.
  26. Reiter I., Krammer B., Schwamberger G. Gutting edge: differential effect of apoptotic versus necrotic tumor cell on macrophage anti tumor activies // J. Immunol. 1999. Vol. 163. P.1730–1732.
  27. Schwartz S., Absolon K., Vermund H. Some relationships of porfyrins, X-rays and tumors // Univ. Minnesota Med. Bul. 1955. Vol. 71. P. 727–732.
  28. Siegel K. A., Fingar V. M., Wieman T. J. Mechanisms of tumor destruction using photofrin, HPPH and N Peb // Photochem. and Photobiol. 1993. Vol. 57. P. 20
  29. Specht K. G., Rodgers M. A. Depolarization of mouse myeloma cell membranes during photodynamic action // J. Photochem. Photobiol. 1990. Vol. 51. P. 319–324.
  30. Tappeiner H., Jesionek A. Therapeutische Versuche mit fluoresziernder Stoffen // Munch. Med. Wochenschr. 1903. Vol. 50. P. 2042.
  31. Taylor A. E., Gibson W., Granger H. J., Guyton A. C. Review in lymphology. The Intraction between Intracapillary and Tissue Forces in the Overall Regulation of Interstitial Fluid Volume // Lymhologe. 1973. Vol. 6. P. 192–208.



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Copyright (c) 2012 Slesarevskaya M.N., Sokolov A.V.

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