Efficiency and tolerability of the anticholinergic therapy in neurogenic bladder overactivity

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The treatment of 50 patients with neurogenic bladder overactivity (NBO) (average age 51,8 ± 5,0 years) was carried out. Solifenacine in a dosage of 5 mg per day was proscribed to all patients. The assessment of efficiency and tolerability of treatment was determined by each two weeks from its beginning. As the main criterion of the assessment’s efficiency we used the quantity of imperative desires decreasing of the III–IV degree (on PPIUS questionnaire) more than for 30% from initial level. At an insufficient efficiency the initial dosage of Solifenacine was increased up to 10 mg once per day. In case of insufficiency of the increased Solifenacine dosage, Tolteradine was proscribed additionally in a dosage of 4 mg per day and the treatment was continued. The general duration of treatment of patients was 12 weeks. The performed research results showed of high efficiency and satisfactory acceptability of NBO scheme of treatment. We estimated the treatment’s results of 38 (76,0%) from 50 treated patients as positive. Thus any patients didn't leave the research due to the side effects of treatment development

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About the authors

Igor Valentinovich Kuzmin

St.-Petersburg State I. P. Pavlov Medical University

Email: kuzminigor@mail.ru
doctor of medical science, professor, Department of Urology

Elena Evgen'evna Lukina

St.-Petersburg State I. P. Pavlov Medical University

Email: luckina.elena@gmail.com
aspirant, Department of Urology


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