Vol 2, No 2 (2012)

The article is devoted to the development of Urology in St.-Petersburg since XVIII-th century and up to now. The main marks of the urological science development are reflected, the contribution to its development by leading urologists — inhabitants of St.-Petersburg is described.

The Aim of study — to investigate the pathogenetic peculiarities of inflammatory process’ development in experiment at its initiation by our offered models of chronic prostatitis reproduction at rats as well as to evaluate the clinical efficiency of pathogenetic therapy and prophylaxis for patients with chronic prostatitis with usage of Prostatilen in suppositories. Material and methods. Research is carried out on 52 not purebred white rats males. They were divided into four groups. In the 1-st group there were intact rats (n = 6). To the rats of the 2-nd group (n = 12) 0,25 ml of dymexide was entered into a rectum, to the rats of the 3-rd group (n = 13) 0,25 ml of turpentine was entered. In the 4-th group there were rats (n = 21) whom into a rectum entered a turpentine mix with dimexide on the model offered by us. In 35 days of rats deduced from experience and the macro — and microscopic investigations of prostate was performed. The clinical part of our research included the efficiency assessment of Prostatilen preventive usage at 26 men with chronic prostatitis, at the age from 18 till 47 years. According to the investigation’s data the complex treatment was carried out.. For the next 5–6 years three times per year we managed to them the 5-day courses of preventive treatment by Prostatilen. It was appointed according to the standard scheme by one suppository at night daily within five days. Results. The analysis of weight factor indicators at rats of the 4-th group (in comparison with corresponding factors in the 2-nd and 3-rd groups) testifies to heavier course of inflammatory process in this group of laboratory animals. The described changes of a microscopic picture of the prostate and vesicular seminalis glands at rats of the 2-nd, 3-rd and 4-th groups are typical for the chronic inflammation of these organs. Results of the carried-out pilot study confirm the leading role of the pathological venous hyperemia in pathogenesis of prostate gland chronic inflammation. According to the data which was received after the clinical data analysis it becomes clear that during a supervision of patients with chronic prostatitis no sign of illness activation was noted during Prostatilen therapy providing. Conclusion. Prostatitis at laboratory animals caused by our technique offer is a typical example of nonspecific inflammatory reaction in response to disorder of local hemodynamic. The complex uses of the etiotropic and pathogenetic therapy remedies in clinical practice at treatment of patients with prostatitis is necessary, as well as for the purpose of its prevention

The aim of study was studying of microcirculation’s condition in the bladder wall at patients with chronic recurrent cystitis. Patient and methods. For the investigation of the bladder wall microcirculation the original technique of intravesical high-frequency ultrasonic dopplerography (USDG) with help of which the study of the bladder wall blood-flow at 37 women with chronic recurrent cystitis was carried out as well as at 32 healthy women from the control group. Results. The method of USDG gave the possibility to estimate the blood-flow condition in the bladder wall at women with chronic cystitis and to establish the existence and extent of its violations. Conclusion. The disorder of the microcirculation can be considered as one of the major factors promoting a chronization and recurrency of the inflammatory process in the bladder wall. The prescription of medications improving the blood-flow in the bladder wall is pathogenetic defensible

At this time positron emission tomography (PET) in combination with computed tomography (CT) — PET/CT is the most promising imaging technique for tumor detection in prostate. Areas of metabolic abnormality on the PET imaging here can be perfectly correlated with anatomical localization on the CT images. The efficiency of this modality could be significantly increased using radiopharmaceuticals targeting specific tumor cells. Such immunohistochemical markers as PSMA, PSCA, GRPR, EpCAM and VEGF are considered to be targets for novel diagnostic imaging techniques and treatment of prostate cancer

Urethroplasty using free oral mucosa grafts is a modern method of urethral strictures disease’s radical treatment in male. There is no consensus on surgical indications and technique. Two case reports of long urethral strictures in male are presented and discussed in this article