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Vol 2, No 2 (2012)


The history of Urology in St.-Petersburg

Tkachuk V.N., Tkachuk l.N.


The article is devoted to the development of Urology in St.-Petersburg since XVIII-th century and up to now. The main marks of the urological science development are reflected, the contribution to its development by leading urologists — inhabitants of St.-Petersburg is described.
Urology reports (St. - Petersburg). 2012;2(2):3-9
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Early and late complications of radical prostatectomy

Al-Shukri S.K., Nevirovich E.S., Kuzmin I.V., Boriskin A.G.


The analysis of radical prostatek-tomiya (RPE) results at 128 patients taking place of treatment in the clinic of urology of SPbGMU named after academician I. P. Pavlov since 2005 till 2012 is carried out. Age of patients was from 52 to 81 year (averagely — 66.0 years). The intraoperative mortality was absent. The intraoperative complications included the injury of rectum at four patients (2.3%) and damage of the ureter at one patient (0.7%). The late complications included a stricture of vesicourethral anastomosis — at five patients (3.9%), an urine incontinence later than 12 months after the operation — at five patients (3.9%). The carried-out statistical analysis didn't reveal any factors which are statistically influenced to the anastomosis stricture development. It is noted that the level of intraoperative hemorrhage and the operation’s duration authentically correlated with the duration of urinary retention recovery after radical prostatektomy
Urology reports (St. - Petersburg). 2012;2(2):10-14
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Pathogenesis and prophylaxis of chronic prostatitis (clinical and experimental study)

Al-Shukri S.K., Gorbachev A.G., Borovets S.Y., Tiurin A.G., Knyazkin I.V.


The Aim of study — to investigate the pathogenetic peculiarities of inflammatory process’ development in experiment at its initiation by our offered models of chronic prostatitis reproduction at rats as well as to evaluate the clinical efficiency of pathogenetic therapy and prophylaxis for patients with chronic prostatitis with usage of Prostatilen in suppositories. Material and methods. Research is carried out on 52 not purebred white rats males. They were divided into four groups. In the 1-st group there were intact rats (n = 6). To the rats of the 2-nd group (n = 12) 0,25 ml of dymexide was entered into a rectum, to the rats of the 3-rd group (n = 13) 0,25 ml of turpentine was entered. In the 4-th group there were rats (n = 21) whom into a rectum entered a turpentine mix with dimexide on the model offered by us. In 35 days of rats deduced from experience and the macro — and microscopic investigations of prostate was performed. The clinical part of our research included the efficiency assessment of Prostatilen preventive usage at 26 men with chronic prostatitis, at the age from 18 till 47 years. According to the investigation’s data the complex treatment was carried out.. For the next 5–6 years three times per year we managed to them the 5-day courses of preventive treatment by Prostatilen. It was appointed according to the standard scheme by one suppository at night daily within five days. Results. The analysis of weight factor indicators at rats of the 4-th group (in comparison with corresponding factors in the 2-nd and 3-rd groups) testifies to heavier course of inflammatory process in this group of laboratory animals. The described changes of a microscopic picture of the prostate and vesicular seminalis glands at rats of the 2-nd, 3-rd and 4-th groups are typical for the chronic inflammation of these organs. Results of the carried-out pilot study confirm the leading role of the pathological venous hyperemia in pathogenesis of prostate gland chronic inflammation. According to the data which was received after the clinical data analysis it becomes clear that during a supervision of patients with chronic prostatitis no sign of illness activation was noted during Prostatilen therapy providing. Conclusion. Prostatitis at laboratory animals caused by our technique offer is a typical example of nonspecific inflammatory reaction in response to disorder of local hemodynamic. The complex uses of the etiotropic and pathogenetic therapy remedies in clinical practice at treatment of patients with prostatitis is necessary, as well as for the purpose of its prevention
Urology reports (St. - Petersburg). 2012;2(2):15-19
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Efficiency and tolerability of the anticholinergic therapy in neurogenic bladder overactivity

Kuzmin I.V., Lukina E.E.


The treatment of 50 patients with neurogenic bladder overactivity (NBO) (average age 51,8 ± 5,0 years) was carried out. Solifenacine in a dosage of 5 mg per day was proscribed to all patients. The assessment of efficiency and tolerability of treatment was determined by each two weeks from its beginning. As the main criterion of the assessment’s efficiency we used the quantity of imperative desires decreasing of the III–IV degree (on PPIUS questionnaire) more than for 30% from initial level. At an insufficient efficiency the initial dosage of Solifenacine was increased up to 10 mg once per day. In case of insufficiency of the increased Solifenacine dosage, Tolteradine was proscribed additionally in a dosage of 4 mg per day and the treatment was continued. The general duration of treatment of patients was 12 weeks. The performed research results showed of high efficiency and satisfactory acceptability of NBO scheme of treatment. We estimated the treatment’s results of 38 (76,0%) from 50 treated patients as positive. Thus any patients didn't leave the research due to the side effects of treatment development
Urology reports (St. - Petersburg). 2012;2(2):20-25
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Assessment of microcirculation’s condition of the bladder wall at women with chronic recurrent cystitis

Slesarevskaya M.N., Kuzmin I.V., Zarkih A.V., Shabudina N.O.


The aim of study was studying of microcirculation’s condition in the bladder wall at patients with chronic recurrent cystitis. Patient and methods. For the investigation of the bladder wall microcirculation the original technique of intravesical high-frequency ultrasonic dopplerography (USDG) with help of which the study of the bladder wall blood-flow at 37 women with chronic recurrent cystitis was carried out as well as at 32 healthy women from the control group. Results. The method of USDG gave the possibility to estimate the blood-flow condition in the bladder wall at women with chronic cystitis and to establish the existence and extent of its violations. Conclusion. The disorder of the microcirculation can be considered as one of the major factors promoting a chronization and recurrency of the inflammatory process in the bladder wall. The prescription of medications improving the blood-flow in the bladder wall is pathogenetic defensible
Urology reports (St. - Petersburg). 2012;2(2):26-31
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Evaluation of the lower urinary tract dysfunction at patients with unsatisfactory results operative treatment benign prostatic hyperplasia

Amdiy R.E., Giorgobiani T.G.


The aim of study: to evaluate the reasons of persisting dysuria after operative treatment benign prostatic hyperplasia (BPH). Patients and methods: complex urological evaluation, including urodynamic study, were performed 73 patients (average age 63,4 ± 1,2 years) with persisting lower urinary tract symptoms after operative treatment BPH. Dysuria continued 3,4 ± 0,5 years. Control group consists of 36 BPH patient with absence dysuria after operative treatment BPH. Average age patients of the control group was 64,1 ± 1,2 years. Results: Persisting dysuria after BPH surgery commonly was caused by detrusor pathology: detrusor hyperactivity and impaired contractility. These conditions were diagnosed at 46 (63,0%) and at 26 (35,6%) patients. At 19 (26%) patients based on results urodynamic study were diagnosed this both detrusor hyperactivity and impaired contractility. Infravesical obstruction was less frequent reason for persisting dysuria and was diagnosed at 9 (12,3%) patients. Based on results urodynamic study stress urinary incontinence due to sphincter impairment was diagnosed at 5 incontinent patients and mixed incontinence due to detrusor dysfunction and sphincter impairment was found out at 16 patients. Conclusion: Urodynamic evaluation patients with unsatisfactory results operative treatment BPH allows to find out reason of dysuria, including incontinence. Persisting dysuria was caused by detrusor hyperactivity or/and impaired detrusor contractility at majority patients
Urology reports (St. - Petersburg). 2012;2(2):32-37
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Novel immunohistochemical markers in early diagnostics of prostate cancer (review)

Ribalov M.A., Al-Shukri S.K., Borovets S.Y.


At this time positron emission tomography (PET) in combination with computed tomography (CT) — PET/CT is the most promising imaging technique for tumor detection in prostate. Areas of metabolic abnormality on the PET imaging here can be perfectly correlated with anatomical localization on the CT images. The efficiency of this modality could be significantly increased using radiopharmaceuticals targeting specific tumor cells. Such immunohistochemical markers as PSMA, PSCA, GRPR, EpCAM and VEGF are considered to be targets for novel diagnostic imaging techniques and treatment of prostate cancer
Urology reports (St. - Petersburg). 2012;2(2):38-40
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Endovideosurgery in urology: technical providing of method

Antonov A.V.


In the second series of lectures devoted to the usage of endovideosurgery in urology the information concerning the technical providing of this method of treatment is presented. The equipment and tools which are necessary for the operative interventions performance are described in details. Practical recommendations about their usage are given
Urology reports (St. - Petersburg). 2012;2(2):41-47
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Substitute urethroplasty using free oral mucosa grafts in treatment of long strictures of anterior urethra

Al-Shukri S.K., Nevirovich E.S., Perekalin P.V., Korneyev I.A., Ilin D.M.


Urethroplasty using free oral mucosa grafts is a modern method of urethral strictures disease’s radical treatment in male. There is no consensus on surgical indications and technique. Two case reports of long urethral strictures in male are presented and discussed in this article
Urology reports (St. - Petersburg). 2012;2(2):48-51
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