Aggressive course of a rare type of urethral cancer in women

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The article provides a clinical case of urethral cancer in women. Primary urethral carcinomas are rare, less than 1% of all malignant tumors. According to the Rarecare Cancer Surveillance Agency for Europe (RARECARE), urethral cancer in women is 0.6 and 1.6 in men per 1 million people per year. A 56-year-old patient with histologically verified clear cell adenocarcinoma of the proximal urethra was monitored for 18 months. An aggressive course of the tumor process has been shown, which led to the need to perform anterior exenteration of the pelvic organs. The histogenesis of primary clear cell urethral adenocarcinoma has not been definitively determined. The atypical external localization in the described case suggests the periurethral origin of this cancerous tumor from the Skene’s glands. The demonstration of a rare form of urethral cancer, clear cell adenocarcinoma, contributes to the accumulation of knowledge about its histopathology and clinical course, as well as increasing cancer alertness in the treatment of urethral diseases in doctors of any specialty.

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About the authors

Olga S. Streltsova

Privolzhskiy Research Medical University

Author for correspondence.
ORCID iD: 0000-0002-9097-0267
SPIN-code: 9674-0382

Russian Federation, Nizhnij Novgorod

Doctor of Medical Science, Professor, Department of Urology named after E.V. Shakhov

Katerina E. Yunusova

Privolzhskiy Research Medical University

ORCID iD: 0000-0001-9283-0332
SPIN-code: 9211-4897

Russian Federation, Nizhnij Novgorod

Candidate of Medical Science, Associate Professor of the Department of Pathological Anatomy

Valentin N. Krupin

Privolzhskiy Research Medical University

ORCID iD: 0000-0002-4887-4888

Russian Federation, Nizhny Novgorod

Doctor of Medical Science, Professor, Head of the Department of Urology named after E.V. Shakhov

Vasiliy V. Vlasov

Privolzhskiy Research Medical University

ORCID iD: 0000-0002-9502-4229

Russian Federation, Nizhnij Novgorod

Candidate of Medical Science, Associate Professor of the Department of Urology named after E.V. Shakhov

Anton S. Kuyarov

Privolzhskiy Research Medical University

ORCID iD: 0000-0003-0503-6128

Russian Federation, Nizhnij Novgorod



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Supplementary files

Supplementary Files Action
Fig. 1. MRI images of the pelvic organs of patient V., 56 y. o.: a – frontal projection, b – sagittal projection. A tumor with a clear outline is located around the urethra

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Fig. 2. The progress of the operation. Isolation of a tumor located around the urethra (a), excision of the tumor (b) with preservation of the neck the bladder and the distal part of the urethra (c)

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Fig. 3. Macropreparations. The urethra is dissected lengthwise, light tumor masses are visible around the urethral fragment and a lesion of ulceration of the mucous membrane (indicated by an arrow)

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Fig. 4. Histological preparations of the urethra with a tumor: a – the mucous membrane of the urethra, there is no tumor growth (stain hematoxylin-eosin, ×40); b – clear cell carcinoma with invasive growth in the outer layers of the urethra (stain hematoxylin-eosin, ×100); c – clear cell carcinoma of the urethra (stain hematoxylin-eosin, ×200)

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Copyright (c) 2020 Streltsova O.S., Yunusova K.E., Krupin V.N., Vlasov V.V., Kuyarov A.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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