Application of pantohematogen dry for treatment of discirculatory disorders in chronic prostatitis (experimental and clinical study)

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Abstract

PURPOSE: To study in experiment and in clinical conditions the effectiveness of the preparation pantogematogen dry, obtained from the blood of a maral, for the correction of dyscirculatory disorders in the prostate gland.

MATERIALS AND METHODS: The experimental and morphological part of the work was performed on 90 male Wistar rats with local venous congestion in the small pelvis due to ligation of the internal iliac veins. Animals of the main group (n = 30) underwent enteral correction with dry pantohematogen (in a daily dose of 10 mg per 100 g of animal weight) starting from the 7th day after modeling the disease, the course was 14 days. The rats of the 2nd group (n = 30) after modeling of venous stasis were not treated. Group 3 consisted of intact animals. During the clinical phase of the study, 61 patients with chronic congestive prostatitis were treated. All patients received standard therapy, and patients in the treatment group (n = 30) additionally received highly dispersed aerosol transrectal irrigation with an aqueous solution of pantohematogen, daily, for a course of 10 procedures.

RESULTS AND DISCUSSION: Morphological examination of the prostate gland of laboratory animals with experimental discirculatory prostatitis and its subsequent enteral correction with panthematogen dry indicated significant differences compared with animals of the 2nd group. A tendency towards restoration of the normal structure of the prostate, its metabolism, regional and organ blood and lymph outflow, improvement of the drainage-detoxification and transport activity of its regional lymph nodes was noted. In the clinical part of the study, the effectiveness of the use of pantogematogen in patients with chronic congestive prostatitis was shown. At the end of the course of treatment in patients of the 1st group, the disappearance of pain (in 72.4% of cases) and dysuric (in 86.2% of cases) syndromes was observed, and in the rest – a decrease in their intensity. According to the TRUS of the prostate in patients of the 1st group, after treatment in 52% of cases, a decrease in the volume of the prostate was noted.

CONCLUSIONS: The results of an experimental clinical study indicate the prospects for the inclusion of pantogematogen in the complex therapy of patients with chronic congestive prostatitis.

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About the authors

Igor V. Tihonov

Stankostroitel Sanatorium

Email: tihonoff2701@yandex.ru

Doctor of Medical Science, Medical Director, Urologist 

Russian Federation, 656045, Altay region, Barnaul, Tihonova street, 33B

Igor I. Tityaev

City Clinical Hospital No.1

Email: den-sk@ya.ru

Doctor of Medical Science, Professor, Urologist of Urology Department

Russian Federation, 630047, Novosibirsk, Zalesskogo street, 6

Denis S. Kasyanov

City Clinical Hospital No.1

Author for correspondence.
Email: kasyanovds@mail.ru

Urologist, Oncologist of the Outpatient Care Center

Russian Federation, 630047, Novosibirsk, Zalesskogo street, 6

Ramil H. Chekushin

Kuzbass Clinical Dermatovenerogical Dispensary

Email: kasyanovds@mail.ru

Dermatovenerologist, Candidate of Medical Science

Russian Federation, 650025, Kemerovo, Rukavishnikova street, 41

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2. Fig. 1. The prostate gland of male Wistar rats with experimental discirculatory prostatitis (а) and after its enteral correction with pantohematogenous dry (b: there is a decrease in the severity of congestion). Stained with hematoxylin-eosin, ×150

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3. Fig. 2. The iliac lymph node of a male Wistar rat with experimental discirculatory prostatitis after enteral correction with dry pantogematogen. There is an increase in cerebral and marginal sinuses. Stained with hematoxylin-eosin. ×150 (а), ×500 (b)

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4. Fig. 3. Results of TRUS of the prostate of a patient with severe congestion (a) and after correction with pantohematogenous highly dispersed aerosol irrigation (b: decrease in the severity of congestion)

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