Comparative morphofunctional visualization of the manifestations of chronic bacterial and radiation bladder injuries

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Abstract

Comparative morphofunctional and histological visualization of bladder wall lesions in 15 patients with chronic bacterial cystitis and in 15 patients with chronic radiation cystitis using positron emission tomography - computed tomography (PET/CT) was performed. The studies have revealed significant differences in the parameters of blood flow and tissue metabolism in patients with these forms of bladder lesions. In patients with chronic bacterial cystitis, an increase in the frequency of urination was accompanied by a decrease in the capacity of the bladder under conditions of a decrease in the velocity of arterial and venous blood flow in its wall as compared with the control. At the same time, at the cellular-molecular level in the bladder wall, no significant metabolic abnormalities, assessed by the SUVmax indicator, were revealed. Chronic radiation cystitis was characterized by a significant increase in the rate of systolic and diastolic blood flow in the bladder wall, its thickening and hypermetabolism of 18F-FDG.

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About the authors

Berdichevsky B. Berdichevskyy

Tyumen State Medical University of the Ministry of Healthcare of the Russian Federation

Email: urotgmu@mail.ru
ORCID iD: 0000-0002-0186-6514
SPIN-code: 9768-5704

Dr. Sci. (Med), Accosiate of Professor of the Department of Oncology with a course of Urology

Russian Federation, 625023, Tyumen, Odesskaya str., 54

Boris A. Berdichevsky

Tyumen State Medical University of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: doktor_bba@mail.ru
ORCID iD: 0000-0002-9414-8510
SPIN-code: 4630-3855

Dr. Sci. (Med), Professor

Russian Federation, 625023, Tyumen, Odesskaya str., 54

Barashin A. Barashin

Tyumen State Medical University of the Ministry of Healthcare of the Russian Federation

Email: dmitry_barashin@mail.ru
SPIN-code: 6553-7593

Cand. Sci. (Med), Assistant of the Department of Oncology with a course of Urology

Russian Federation, 625023, Tyumen, Odesskaya str., 54

Artem A. Keln

Tyumen State Medical University of the Ministry of Healthcare of the Russian Federation

Email: artyom-keln@ya.ru
SPIN-code: 9633-0276

Cand. Sci. (Med), Assistant of the Department of Oncology with a course of Urology

Russian Federation, 625023, Tyumen, Odesskaya str., 54

Anton A. Naletov

Tyumen State Medical University of the Ministry of Healthcare of the Russian Federation

Email: annaletov@mail.ru
SPIN-code: 8946-2000

Assistant of the Department of Oncology with a course of Urology

Russian Federation, 625023, Tyumen, Odesskaya str., 54

Aleksej L. Boldyrev

Tyumen State Medical University of the Ministry of Healthcare of the Russian Federation

Email: doktor_bba@mail.ru

Postgraduate, Department of Oncology with a course of Urology

Russian Federation, 625023, Tyumen, Odesskaya str., 54

Elena I. Gutrova

Tyumen State Medical University of the Ministry of Healthcare of the Russian Federation

Email: doktor_bba@mail.ru

Postgraduate, Department of Oncology with a course of Urology

Russian Federation, 625023, Tyumen, Odesskaya str., 54

References

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Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Functional and morphological visualization of microbial-inflammatory and radiation damage to the bladder: I – uroflowmetry; II – ultrasonography of the bladder with Doppler ultrasonography; III – cystoscopy. a – control group; b – chronic bacterial cystitis; c – chronic radiation cystitis

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3. Fig. 2. Comparative molecular cell and histological imaging of chronic bacterial and chronic and radiation damage to the bladder: I – native positron emission tomography of the upper and lower urinary tract; II – combined positron emission tomography with computed tomography of the bladder; III – histological examination of the bladder wall (stain hematoxylin-eosin). a – control group; b – chronic bacterial cystitis; c – chronic radiation cystitis

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