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Pathomorphology of adaptive changes in the remaining kidney in the early postoperative period after nephrectomy
- 作者: Shormanov I.S.1, Los M.S.2, Kosenko M.V.3, Shormanova N.S.1
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隶属关系:
- Yaroslavl State Medical University of the Ministry of Healthcare of the Russian Federation
- Regional Clinical Hospital
- Federal State Budgetary Educational Institutionof Higher Education "Yaroslavl State Medical University" of the Ministry of Healthcare of the Russian Federation
- 期: 卷 10, 编号 1 (2020)
- 页面: 19-24
- 栏目: Original articles
- URL: https://journals.eco-vector.com/uroved/article/view/13378
- DOI: https://doi.org/10.17816/uroved10119-24
- ID: 13378
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Objective. To study the adaptive capacity of a single remaining kidney in the early postoperative period of nephrectomy in an experiment.
Materials and methods. The experiment involved 35 laboratory white rats, which were divided into three experimental groups. Group 1 (n = 5) intact animals, group 2 (n = 15) animals underwent nephrectomy on the left; group 3 (n = 15) animals underwent nephrectomy and additionally were created 90 minute hypoxic hypoxia. Histological material was collected on the 5th, 21st and 60th days after surgery.
Results. Characteristic morphological changes in the only remaining kidney were an increase in the size of the glomeruli and a decrease in their number. Nephron fibrosis was detected, accompanied by increased production of antigens by the tubular epithelium, which is likely a response to a cascade increase in oxidative stress and increased release of cytokines that stimulate the production of intrarenal collagen.
Conclusion. Nephrectomy and hypoxia are provocateurs for the development of systemic distress syndrome, the result of which is the formation of a “vicious pathogenetic circle”, which reduces the functionality of the renal tissue. This can be considered as one of the early preclinical mechanisms for the initiation of single kidney disease in the future.
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作者简介
Igor Shormanov
Yaroslavl State Medical University of the Ministry of Healthcare of the Russian Federation
Email: i-s-shormanov@yandex.ru
SPIN 代码: 7772-8420
Scopus 作者 ID: 6507085029
Doctor of Medical Sciences, Professor, Head of the Department of Urology with Nephrology
俄罗斯联邦, YaroslavlMarina Los
Regional Clinical Hospital
编辑信件的主要联系方式.
Email: 922099@mail.ru
Candidate of Medical Sciences, Urologist
俄罗斯联邦, YaroslavlMaxim Kosenko
Federal State Budgetary Educational Institutionof Higher Education "Yaroslavl State Medical University" of the Ministry of Healthcare of the Russian Federation
Email: Maxim.kosenko76@yandex.ru
Senior Lecturer, Department of Physical Culture and Sports
俄罗斯联邦, YaroslavlNatalia Shormanova
Yaroslavl State Medical University of the Ministry of Healthcare of the Russian Federation
Email: i-s-shormanov@rambler.ru
Assistant of the Department of Pathological Anatomy
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