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Possibilities of proteolytic enzymes in the treatment of some forms of male infertility
- 作者: Neymark A.I.1, Neymark B.A.1, Nozdrachev N.A.1, Davydov A.V.1, Kablova I.V.1, Yakovets Y.V.1, Levin V.P.1, Plotnikova A.Y.1
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隶属关系:
- Altai State Medical University of the Ministry of Healthcare of the Russian Federation
- 期: 卷 10, 编号 3 (2020)
- 页面: 217-221
- 栏目: Original articles
- URL: https://journals.eco-vector.com/uroved/article/view/35132
- DOI: https://doi.org/10.17816/uroved35132
- ID: 35132
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In the study 46 men with impaired fertility and the presence of viscosipathy were included. The patients’ age ranged from 22 to 45 years, the average duration of infertility in marriage was 3.5 ± 2.4 years. All patients with Longidaza drugs according to the following scheme were treated. First, ten intramuscular injections of Longidaza® lyophilisate were performed to prepare a solution of 3000 IU once every five days, then Longidaza® suppositories 3000 IU rectally once every three days were prescribed, for a total of 15 suppositories. The total duration of the course of treatment is 90 days. A decrease in sperm viscosity from 2.1 ± 0.05 cm to 0.6 ± 0.07 cm (p < 0.05), an increase in total sperm motility (from 32.6 ± 2.9 to 61 ± 3.1%, p < 0.05) and the number of sperm with progressive movement (from 22 ± 1.1 to 36.7 ± 2.9 %, p < 0.05) after the treatment were revealed. Also, in the course of treatment, the restoration of the antioxidant protection of the ejaculate was noted, as evidenced by an increase in the activity of glutathione peroxidase and superoxide dismutase and a decrease in the content of malon dialdehyde. During the first year after the end of treatment, conception in marriage was registered in 21 (45.7%) patients. The results of the study indicate that a violation of the lipid peroxidation system can lead to both an increase in sperm viscosity and a disruption in the activity of acrosomal enzymes, as a result of which it becomes difficult for spermatozoa to penetrate the ovum. Longidaza is able to increase the hyaluronidase activity of the sperm acrosome, thereby improving the fertilizing ability of the ejaculate.
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作者简介
Aleksandr Neymark
Altai State Medical University of the Ministry of Healthcare of the Russian Federation
Email: neimark.a@mail.ru
ORCID iD: 0000-0002-5741-6408
Scopus 作者 ID: 7102411541
https://asmu.ru/ob-universitete/fakultety/lechebnyy-fakultet/spetsializirovannoy-khirurgii-po-urologii-travmatologii-i-oftalmologii/#
Doctor of Medical Science, Professor, Head of the Department of Urology and Andrology with Course of Additional Professional Education
俄罗斯联邦, BarnaulBoris Neymark
Altai State Medical University of the Ministry of Healthcare of the Russian Federation
Email: neimark.b@mail.ru
ORCID iD: 0000-0001-8009-3777
https://asmu.ru/ob-universitete/fakultety/lechebnyy-fakultet/spetsializirovannoy-khirurgii-po-urologii-travmatologii-i-oftalmologii/#
Doctor of Medical Science, Professor of the Department of Urology and Andrology with Course of Additional Professional Education
俄罗斯联邦, BarnaulNikolay Nozdrachev
Altai State Medical University of the Ministry of Healthcare of the Russian Federation
Email: nozdrachevuro@mail.ru
ORCID iD: 0000-0001-9203-3499
Candidate of Medical Science, Associated Professor of the Department of Urology and Andrology with Course of Additional Professional Education
俄罗斯联邦, BarnaulAndrej Davydov
Altai State Medical University of the Ministry of Healthcare of the Russian Federation
Email: andre1763@mail.ru
ORCID iD: 0000-0001-8212-2623
Doctor of Medical Science, Professor of the Department of Urology and Andrology with Course of Additional Professional Education
俄罗斯联邦, BarnaulIrina Kablova
Altai State Medical University of the Ministry of Healthcare of the Russian Federation
编辑信件的主要联系方式.
Email: irina_kablova@mail.ru
ORCID iD: 0000-0002-3450-3875
Candidate of Medical Science, Associated Professor of the Department of Urology and Andrology with Course of Additional Professional Education
俄罗斯联邦, BarnaulYaroslava Yakovets
Altai State Medical University of the Ministry of Healthcare of the Russian Federation
Email: yyakovec@mail.ru
ORCID iD: 0000-0001-5974-6534
Candidate of Medical Science, Associated Professor of the Department of Urology and Andrology with Course of Additional Professional Education
俄罗斯联邦, BarnaulVladimir Levin
Altai State Medical University of the Ministry of Healthcare of the Russian Federation
Email: urologagmu@mail.ru
ORCID iD: 0000-0001-9203-3499
Candidate of Medical Science, Assistant Professor of the Department of Urology and Andrology with Course of Additional Professional Education
俄罗斯联邦, BarnaulAnzhelika Plotnikova
Altai State Medical University of the Ministry of Healthcare of the Russian Federation
Email: urologagmu@mail.ru
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