Lesion of the mucous membrane of the stomach, caused by chlamydia in children with chronic glomerulonephritis

Cover Page

Abstract


We studied biopsies of gastric mucosa and the gastric antrum bodies obtained from 60 children with chronic gastritis and chronic gastritis in combination with chronic glomerulonephritis. Clinical data of patients (age, gender, duration of the underlying disease, conducted therapy, the results of laboratory and instrumental studies) were studied. It conducts research using histological and immunohistochemical methods. A morphological study of the sections found gastrobiopsies characteristic manifestations of chronic gastritis c signs of chlamydial lesions. The immunohistochemical method determined Chlamidia trachomatis antigens in the antrum and corpus. The positive expression in the epithelial cells of glands and endothelial microvascular gastric mucosa with concomitant lesions of the stomach and kidneys. The possibility of the development of chronic gastritis chlamydial infection in chronic glomerulonephritis. Based on the obtained results was made comprehensive assessment of the gastric mucosa based on morphological, immunohistochemical and clinical data. The features of stromal-vascular responses in the development of chronic gastritis occurring in isolation and combined with chronic glomerulonephritis. The effect of steroid therapy, as a cause of decrease in protective mechanisms of gastric mucosa in children. The data supporting the need for immunohistochemical studies for the etiologic diagnosis of chronic gastritis and the subsequent selection of appropriate therapy.


Elena V Chikulaeva

Author for correspondence.
elena_chikulaeva@mail.ru
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation, Saint Petersburg, Russia

Department of Pathological Anatomy at the Rate of Forensic Medicine

Valentina F Melnikova

melnikova.val@yandex.ru
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation, Saint Petersburg, Russia

MD, PhD, Dr Med Sci Professor. Department of Pathological Anatomy at the Rate of Forensic Medicine

Ruslan A Nasyrov

ran.53@mail.ru
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation, Saint Petersburg, Russia

MD, PhD, Dr Med Sci Professor Head. Department of Pathological Anatomy at the Rate of Forensic Medicine

  • Аравийская Е.А., Красносельских Т.В., Соколовский Е.В. Кожный зуд. Акне. Урогенитальная хламидийная инфекция. – СПб.: Сотис, 1998. – C. 131–133. [Araviyskaya EA, Krasnosel’skikh TV, Sokolovskiy EV. Kozhnyy zud. Akne. Urogenital’naya khlamidiynaya. Saint Petersburg: Sotis; 1998. P. 131-133. (In Russ.)]
  • Аруин Л.И., Капуллер Л.Л., Исаков В.А. Международная классификация хронического гастрита: что следует принять и что вызывает сомнения // Архив патологии. – 2009. – T. 71. – № 4. – С. 11–17. [Aruin LI, Kapuller LL, Isakov VA. Mezhdunarodnaja klassifikacija hronicheskogo gastrita: chto sleduet prinjat’ i chto vyzyvaet somnenija. Arkhiv patologii. 2009;71(4):11-17. (In Russ.)]
  • Волынец Г.В., Хавкин А.И., Филатов Ф.П. Этиологическая характеристика основных типов хронического гастрита у детей // Русский медицинский журнал. – 2005. – Т. 13. – № 18. – С. 1208–1213. Volynets GV, Khavkin AI, Filatov FP. Jetiologicheskaja harakteristika osnovnyh tipov hronicheskogo gastrita u detej. Russkij Medicinskij Zhurnal. 2005;13(18):1208-1213. (In Russ.)]
  • Звягин А.А. Аутоиммунный гастрит у детей с аутоиммунными заболеваниями // Педиатр. – 2013. – Т. 4. – № 4. – С. 44–47. [Zvyagin AA. Аutoimmune gastritis in children with autoimmune diseases. Pediatr (St Peterburg). 2013;4(4):44-47. (In Russ.)]
  • Канькова Н.Ю., Жукова Е.А, Широкова Н.Ю., Видманова Т.А. Особенности поражения слизистой оболочки желудка и двенадцатиперстной кишки у детей с хроническим гастродуоденитом при различном составе микрофлоры // Вестник Российской академии наук. – 2014. – Т. 69. – № 9–10. – С. 51–56. [Kankova NY, Zhukova EA, Shirokova NY, Vidmanova TA. Osobennosti porazhenija slizistoj obolochki zheludka i dvenadcatiperstnoj kishki u detej s hronicheskim gastroduodenitom pri razlichnom sostave mikroflory. Vestnik Rossijskoj akademii nauk. 2014;69(9-10):51-56. (In Russ.)]. doi: 10.18413/2313-8955-2014-1-1-31-36.
  • Капустина Т.А., Белова Е.В. Особенности течения верхнечелюстного синусита у детей c верифицированной хламидийной инфекцией // Вестник Российской академии медицинских наук. – 2013. – T. 68. – № 10. – С. 22. [Kapustina TA, Belova EV. Osobennosti techenija verhnecheljustnogo sinusita u detej c verificirovannoj hlamidijnoj infekciej. Vestnik Rossijskoj akademii medicinskih nauk. 2013;68(10):22. (In Russ.)]
  • Ларина Л.Е. Роль хламидийной инфекции в формировании воспалительной патологии мочевой системы у детей: автореф. дис. … канд. мед. наук: 14.00.09; Российский государственный медицинский университет. – М., 2003. – C. 137. [Larina LE. Rol’ khlamidiinoi infektsii v formirovanii vospalitel’noi patologii mochevoi sistemy u detei [dissertaion]. 14.00.09. Rossiiskii gosudarstvennyi Meditsinskii universitet. Moscow; 2003. P. 137. (In Russ.)]

Supplementary files

There are no supplementary files to display.

Views

Abstract - 14

PDF (Russian) - 51


Copyright (c) 2017 Chikulaeva E.V., Melnikova V.F., Nasyrov R.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.