Genetic markers of celiac disease: modern concern


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Abstract

According to the results of recent scientific studies there is a strong evidence to characterize celiac disease as genetic disorder associated with antigens of major histocompatibility complex (MCH II) HLA-DQ2 and HLA-DQ8. Different loci of HLA molecules are encoded by specific alleles and their combination determines the individual risk of celiac disease formation. In this article authors discuss data on structure of DQ2 and DQ8 molecules, the frequency of different alleles detection in celiac patients and possible classification of genetic risk of celiac disease formation according to HLA-DQ genotype.

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About the authors

Irina Nikolayevna Zakharova

Russian Medical Academy of Postgraduate Education

Email: zakharova-rmapo@yandex.ru
MD, PhD, Dr Med Sci, Professor, Head, Dept. of Pediatrics

Tatyana Eduardovna Borovik

Scientific Center of Children’s Health of Russian Academy of Medical Sciences

Email: borovik@nczd.ru
MD, PhD, Dr Med Sci, Professor, Head, Dept. of Healthy and Sick Child Nutrition

Yelena Aleksandrovna Roslavtseva

Scientific Center of Children’s Health of Russian Academy of Medical Sciences

Email: roslikea@gmail.com
MD, PhD, Senior researcher, Department of Healthy and Sick Child Nutrition

Yelena Nikolayevna Kasatkina

Tushinskaya Children’s Hospital

Email: andren-med@mail.ru
MD, PhD, Pediatrician

Yuliya Andreyevna Dmitriyeva

Russian Medical Academy of Postgraduate Education

Email: jadmitrieva@mail.ru
MD, PhD, Assistant Professor, Department of Pediatrics

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Copyright (c) 2014 Zakharova I.N., Borovik T.E., Roslavtseva Y.A., Kasatkina Y.N., Dmitriyeva Y.A.

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