Whooping cough in children: epidemiological risks, modern tactics of treatment and immunization

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Abstract

The article considers the main features of the epidemiological process of whooping cough in children. Trouble factors were identified, in particular, the emergence of new pathogens, such as Bordetella Holmesii, Bordetella bronchiseptica and oth., the fading of post-vaccination immunity in children before entering school, the complexity of diagnosis and the severity of the infection at an early age, as well as the atypical course of the disease in older schoolchildrens. It is important to understand the epidemiology of whooping cough during the transition to an acellular vaccine, the difficulties of introducing the 2nd round of revaccination of the child population and the need to expand this practice throughout the country, to compete for the possibility of introducing an additional booster dose in adolescence, to organize vaccination of pregnant women and use the “cocoon” strategy in domestic practice. The mass transition to vaccines with an acellular component, of course, makes it possible to increase parents’ confidence in immunoprophylaxis, vaccination coverage, as well as reduce the trauma and reactogenicity of the vaccination procedure. Topical problems of diagnosis and treatment of whooping cough are highlighted from the standpoint of evidence-based medicine.

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About the authors

Konstantin I. Grigoryev

Pirogov’s Russian National Research Medical University of the Ministry of Health of Russia

Email: k-i-grigoryev@yandex.ru

Doctor of Medicine, Professor of the Department of Pediatrics with Infectious Diseases in Children of the Faculty of Additional Professional Education

Russian Federation, Moscow

Olga N. Solodovnikova

City Clinical Hospital No. 40 DZM

Email: k-i-grigoryev@yandex.ru

Candidate of Medical Sciences, Deputy Chief Physician for Infection

Russian Federation, Moscow

Yuliya N. Khlypovka

City Clinical Hospital No. 40 DZM

Email: k-i-grigoryev@yandex.ru

Candidate of Medical Sciences, Head of the Children’s Infectious Diseases Department

Russian Federation, Moscow

Lyudmila F. Nemtyreva

Moscow Financial and Industrial University «Synergy»

Author for correspondence.
Email: k-i-grigoryev@yandex.ru

Honored Health Worker of the Russian Federation, Assistant of the Department of Nursing

Russian Federation, Moscow

References

  1. Uchaikin V.F., Shamsheva O.V. Infectious diseases in children: a textbook. – M.: GEOTAR-Media, 2021. 920 p.
  2. Mazankova L.N., Grigoriev K.I. Pertussis: old infection, new problems. Nurse/ Meditsinskaya sestra. 2018. V. 20. No. 2. S. 19–27.
  3. Chuprinina R.P., Ozeretskovsky N.A., Alekseeva I.A. Immunoprophylaxis and incidence of whooping cough. Present and future. Epidemiology and Vaccinal Prevention/Epidemiologiya i Vaktsinoprofilaktika. 2014; 6(79): 89–99.
  4. Clark TA. Changing pertussis epidemiology: everything old is new again. The Journal of infectious diseases. 2014; 209(7):978–981. doi: 10.1093/infdis/jiu001.
  5. European Centers for Disease Prevention and Control.: Pertussis. Annual Epidemiological Report for 2017. https://www.ecdc.europa.eu/en/publications–data/pertussis–annual–epidemiological–report–2017. Accessed Aug 2020.
  6. Borisova O.Yu. Gadua N.T., Pimenova A.S., еt al. The structure of the population of pertussis pathogen strains in Russia. Epidemiology and Vaccinal Prevention/ Epidemiologiya i Vaktsinoprofilaktika. 2016; 4 (89): 22–27.
  7. Martin S.W., Pawloski L., Williams M., et al. Pertactin–negative Bordetella pertussis strains: evidence for a possible selective advantage. Clin. Infectious Dis. 2015; 60: 223 – 227.
  8. Esposito S, Principi N. Immunization against pertussis in adolescents and adults. Clin Microbiol Infect. 2016; 22(Suppl 5): 89–95.
  9. Agger WA, Naik RM. How should we approach adolescent and adult pertussis? WMJ. 2006;105(1): 47–51.
  10. Fernandez-Cano MI, Armadans G.L, Martinez G.X, еt al. Incidence of whooping cough in Spain (1997–2010): an underreported disease. Eur J Pediatr 2014; 173 (6): 721–726. doi: 10.1007/s00431-013-2228-8.
  11. European Centers for Disease Prevention and Control.: Pertussis. Annual Epidemiological Report for 2018. https://www.ecdc.europa.eu/en/publications-data/pertussis-annual-epidemiological-report-2018.
  12. Martynova G.P., Kuznetsova N.F., Gracheva N.M., еt al. Clinical guidelines (treatment protocol) for the provision of medical care to children with whooping cough. M. Krasnoyarsk, 2013: 60 p.
  13. Kilgore P.E., Salim A.M., Zervous M.J., et al. Pertussis: Microbiology, Disease, Treatment, and Prevention. Clinical Microbiology Reviews. 2016; 29 (3): 449–486. Available from Internet: http://cmr.asm.org/content/29/3/449.
  14. Gadua N.T., Borisova A.B., Pimenova A.S., et al. Identification of Bordetella holmesii among patients hospitalized with suspected whooping cough or pertussis–like diseases. Journal of Infectology/ Zhurnal infektologii. 2019; Vol 11, No 2: 45–49. doi: 10.22625/2072-6732-2019-11-2-45-52.
  15. Babachenko I.V., Kharit S.M., Popova O.P., et al. Whooping cough in children: wedge. recommendations. M.: MZ RF, 2019: 49 p.
  16. Nesterova Yu. V. Clinical and laboratory features of whooping cough in children in modern conditions: Abstract of the thesis. c.m.s. St. Petersburg, 2020: 22 p.
  17. Khlynina Yu.O., Kramar L.V., Arova A.A., et al. Whooping cough in children: clinic, diagnosis, treatment. Medicinal Bulletin/ Lekarstvennyy vestnik. 2017; Volume 1. No. 4 (68): 34–39.
  18. Popova O.P., Gorelov A.V. Modern aspects of whooping cough in children. GEOTAR-Media, 2017: 192 p.
  19. Popova O.P., Mazankova L.N., Skirda T.A., Et al Clinical and diagnostic features of whooping cough in older children. Rosvestn perinatol and pediatrician/ Ros vestn perinatol i pediatr. 2019; 64:(4): 70–75. doi: 10.21508/1027-4065-2019-64-4-70-75.
  20. Bogvilene Ya.A., Martynova G.P., Evreimova S.V., Et al Whooping cough in children: clinical and epidemiological features, the possibility of vaccination at the present stage. Epidemiology and Vaccinal Prevention/ Epidemiologiya i Vaktsinoprofilaktika. 2021; 20(6): 56–62. 10.31631/2073-3046-2021-20-6-56-62' target='_blank'>https://doi: 10.31631/2073-3046-2021-20-6-56-62.
  21. Gavrilova O.A. Clinical and laboratory features of whooping cough in children against the background of vaccination: Abstract of the thesis. …c.m.s. Minsk, 2020: 22 p.
  22. Krasnov V.V., Ilyanenkov K.F., Pavlovich L.R., Et al Whooping cough in children of the first year of life. Children’s infections/ Detskiye infektsii. 2018; 17(1): 12–17. DOI: http://dx.doi.org/10.22627/2072-8107-2018-17-1-12-17.
  23. Kramar L.V., Kaplunov K.O. A case of severe complicated course of whooping cough in a child with concomitant infections. Volgograd Scientific Medical Journal/ Volgogradskiy nauchno-meditsinskiy zhurnal. 2017; 2: 51–53.
  24. Volchok A. Whooping cough: a cough that kills. A collection of the best popular science articles of 2020. /Journalist of the Year Award Rusnano Russian Sci&Tech Writer of the Year, 2020: 52–60.
  25. WHO. Pertussis vaccines: WHO position paper — August 2015. Weekly Epidemiol Rec. 2015; 90: 433–460. http://www.who.int/entity/wer/2015/wer9035.pdf
  26. Bakhmutskaya E.V., Mindlina A.Ya., Stepenko A.V. Whooping cough – incidence, immunization tactics and diagnostic methods in various European countries. Epidemiology and Vaccinal Prevention/Epidemiologiya i Vaktsinoprofilaktika. 2018;17(2):71–82.
  27. Tatochenko V.K. Whooping cough is an uncontrollable infection. Questions of modern pediatrics/ Voprosy sovremennoy pediatrii. 2014; 13(2): 78–82.
  28. Klein N. P., Bartlett J., Fireman B., Baxter R. Waning Tdap Effectiveness in Adolescents. Pediatrics. 2016;137(3):e20153326. doi: 10.1542/peds.2015-3326.
  29. Hardy-Fairbanks A.J., Pan S.J., Decker M.D., Johnson D.R., Greenberg D.P., Kirkland K.B., Talbot E.A., Bernstein H.H. Immune responses in infants whose mothers received Tdap vaccine during pregnancy. Pediatr. Infect. Dis. J. 2013; 32 (11): 1257–1260. doi: 10.1097/INF.0b013e3182a09b6a.

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