Peptic ulcer and helicobacteriosis 39

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Peptic ulcer is a chronic relapsing disease characterized by the formation of a defect in the wall of the stomach and / or duodenum. The incidence of upper gastrointestinal bleeding is 30-150 per 100,000 adults per year, and in most cases they result in hospitalization. In 68% of cases, people are over 60 years old, and 27% are over the age of 80 years. Mortality from PU continues to be high (5-10%, up to 15%). The cause of occurrence is a combination of predisposing internal (genetic markers, microflora) and external factors. A significant contribution to the development of peptic ulcer is prescribed by the bacteria Helicobacter pylori. At the moment, as a conservative treatment, it is recommended to focus on antibiotic therapy in order to eliminate the pathogen and reduce its pathological effect on the wall of the affected organ. Of the available spectrum of antibiotics, metronidazole is considered the most suitable, since it has high activity against Helicobacter pylori when administered orally, efficiency in short courses of treatment, high bioavailability, good penetration into organs and tissues.

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Vsevolod V. Skvortsov

Federal State Budgetary Educational Institution of Higher Education «Volgograd state medical university» of the ministry of health of the Russian Federation

Author for correspondence.
Dr. of Medical sciences, Associate Professor of the Department of Internal Medicine

Ekaterina M. Skvortsova

Federal State Budgetary Educational Institution of Higher Education «Volgograd state medical university» of the ministry of health of the Russian Federation; Clinic «Medsi» OPV Volgograd

general practitioner

Elena V. Belyakova

Federal State Budgetary Educational Institution of Higher Education «Volgograd state medical university» of the ministry of health of the Russian Federation

PhD in Medical Sciences, Associate Professor of the Department of Internal Medicine

Anastasia R. Ponomareva

Federal State Budgetary Educational Institution of Higher Education «Volgograd state medical university» of the ministry of health of the Russian Federation


Nikita D. Matveev

Federal State Budgetary Educational Institution of Higher Education «Volgograd state medical university» of the ministry of health of the Russian Federation



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