Woolly-flowered astragalus (Astragalus dasyanthus Pell.) is the most promising source of non-toxic organic selenium

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Abstract

The biological role of selenium in the human body and the possible consequences of an overdose of the microelement are considered. An assessment is given of the most common forms of the mineral in the composition of pharmaceutical preparations in terms of the effectiveness of eliminating selenium deficiency and safety. Particular attention is paid to the organic form of selenium — selenocysteine. The advantages of using selenium hyperaccumulating plants in the treatment of selenium deficiency conditions are discussed. The information about Astragalus dasyanthus Pell. as a plant-concentrator of selenium is presented. A method of biofortification with L-selenocystin is described, which makes it possible to increase the concentration of selenium in the aerial part of astragalus up to 70 mсg per 100 mg of its dry weight. The characteristics of Russian selenium-containing preparations based on astragalus woolly-flowered, grown using the method of biofortification with L-selenocystin, are given.

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About the authors

Pavel A. Poluboyarinov

FGBOU HE «Penza State University»

Author for correspondence.
Email: 79502304876@yandex.ru
ORCID iD: 0000-0001-9870-0272

Candidate of Agricultural Sciences, Associate Professor, Associate Professor Department of «General and Clinical Pharmacology»

Russian Federation, Penza

Inessa Y. Moiseeva

FGBOU HE «Penza State University»

Email: moiseeva_pharm@mail.ru
ORCID iD: 0000-0003-1168-2871

Doctor of Medical Sciences, Professor, Head of the Department of General and Clinical Pharmacology

Russian Federation, Penza

Alexander V. Fedorov

Federal State Budgetary Educational Institution of Higher Education «Penza State Agrarian University»

Email: F.058@yandex.ru
Russian Federation, Пенза

Villory I. Strukov

Penza Institute for Advanced Medical Education – branch of the Federal State Budgetary Educational Institution of Advanced Medical Education «Russian Medical Academy of Postgraduate Education» of the Ministry of Health of the Russian Federation

Email: villor3737@yandex.ru
ORCID iD: 0000-0003-0959-3933

Doctor of Medical Sciences, Professor, Professor, Professor of «Pediatrics» Department

Russian Federation, Penza

Marina Yu. Sergeyeva-Kondrachenko

Penza Institute for Advanced Medical Education – branch of the Federal State Budgetary Educational Institution of Advanced Medical Education «Russian Medical Academy of Postgraduate Education» of the Ministry of Health of the Russian Federation

Email: marserkon@mail.ru

Doctor of Medical Sciences, Head of the Department of «Therapy, General Medical Practice, Endocrinology, Gastroenterology and Nephrology»

Russian Federation, Penza

Olga P. Vinogradova

Penza Institute for Advanced Medical Education – branch of the Federal State Budgetary Educational Institution of Advanced Medical Education «Russian Medical Academy of Postgraduate Education» of the Ministry of Health of the Russian Federation

Email: o_vinogradova69@mail.ru
ORCID iD: 0000-0002-9094-8772

Doctor of Medical Sciences, Professor, Head of the Department of «Obstetrics and Gynecology»

 

Russian Federation, Penza

Alla G. Denisova

Penza Institute for Advanced Medical Education – branch of the Federal State Budgetary Educational Institution of Advanced Medical Education «Russian Medical Academy of Postgraduate Education» of the Ministry of Health of the Russian Federation

Email: denisovaag@piuv.ru
ORCID iD: 0000-0002-7453-8335

Doctor of Medical Sciences, Deputy Director for Science and Development, Professor of the Department of Therapy, Cardiology, Functional Diagnostics and Rheumatology

Russian Federation, Penza

Denis V. Vikhrev

Penza Institute for Advanced Medical Education – branch of the Federal State Budgetary Educational Institution of Advanced Medical Education «Russian Medical Academy of Postgraduate Education» of the Ministry of Health of the Russian Federation

Email: 79502304876@yandex.ru

Candidate of Medical Sciences, Director

Russian Federation, Penza

Elena S. Panina

FGBOU HE «Penza State University»

Email: panina.es@mail.ru
ORCID iD: 0000-0002-0682-5586

Candidate of Medical Sciences, Associate Professor, Department of General and Clinical Pharmacology

Russian Federation, Penza

Elena V. Petrova

FGBOU HE «Penza State University»

Email: petrovaelena2010@yandex.ru
ORCID iD: 0000-0002-5941-8300

Candidate of Medical Sciences, associate professor, head of department «Neurology, Neurosurgery and Psychiatry»

Russian Federation, Penza

Svetlana S. Burmistrova

Ryazan State Medical University named after Acad. I.P. Pavlov

Email: beeliliya@mail.ru

resident

Russian Federation, Penza

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