Clinical and virological problems of sudden exanthema in children

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The problem of sudden exanthema/children’s roseola, an infection caused by HHV 6, is very relevant in our country. Domestic and foreign experts are actively studying the structure of the virus, the features of clinical forms and course options, methods for diagnosing infection, co-infection with other herpes viruses. It has been established that the immediate environment plays a leading role in the spread of infection. A review of recent data on sudden exanthema makes it clear why healthcare professionals retain such an unusual name for herpesvirus type 6 infection. The underdiagnosis of this disease in our country is associated with a lack of knowledge and alertness on the part of doctors and medical personnel. Although modern clinical and laboratory criteria for diagnosing HHV-6 infection make it possible to quite convincingly diagnose the disease with a fairly high degree of certainty. If desired. The advantage is the use of a technique for detecting virus DNA in plasma and other body media, in combination with serological research methods. The article presents modern recommendations for the treatment and prevention of sudden exanthema

Keywords

Full Text

Restricted Access

About the authors

Konstantin I. Grigorуev

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: k-i-grigoryev@yandex.ru
ORCID iD: 0000-0002-4546-1092

Doctor of Medical Science, professor of depatment of pediatrics with infectious diseases

Russian Federation, Moscow

Lyubov A. Kharitonova

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation

Email: medsestra@rusvrach.ru

Doctor of Medical Science, professor of Department of Pediatrics with Infectious Diseases in Children of the Faculty of Continuing Professional Education

Russian Federation, Moscow

Lyudmila F. Nemtyreva

University «SYNERGY»

Email: medsestra@rusvrach.ru
ORCID iD: 0000-0003-3941-713X

Honored Healthcare Worker of the Russian Federation, Lecturer of the Department of Nursing Management and Social Work of the Faculty of Medicine

Russian Federation, Moscow

Natalia M. Shustikova

University «SYNERGY»

Email: medsestra@rusvrach.ru
ORCID iD: 0000-0002-4400-3583

Candidate of Medical Sciences, Head of the Department of Nursing Management and Social Work, Faculty of Medicine

Russian Federation, Moscow

References

  1. Agut H., Bonnafous P., Gautheret-Dejean A. Human Herpesviruses 6A, 6B, and 7. Microbiology Spectrum. 2016; 4 (3): 1–18. DOI: https://doi.org/10.1128/microbiolspec.DMIH2-0007-2015
  2. International Committee on Taxonomy of Viruses (ICTV). Available at: https://talk.ictvonline.org/.
  3. Guide to the epidemiology of infectious diseases (in 2 volumes). V. 1 / N.I. Briko, G. G. Onishchenko, V.I. Pokrovsky. M.: MIA, 2019: 577–585. [in Russ.]
  4. Adams M. J., Carstens E. B. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses. Archives of virology. 2012; 157 (7): 1411–1422. doi: 10.1007/s00705-012-1299-6.
  5. Phan T.L., Lautenschlager I., Razonable R.R. et al. HHV-6 in liver transplantation. Liver Int. 2018; 38 (2): 210–223. doi: 10.1111/liv.13506.
  6. Ward K.N. Child and adult forms of human herpesvirus 6 encephalitis: looking back, looking forward. Curr Opin Neurol. 2014; 27 (3): 349–355. doi: 10.1097/WCO.0000000000000085.
  7. Muzicа A.D. Diagnosis, clinical and laboratory features and treatment of active forms of herpes virus type 6 infection in children. Abstract diss. …c.m.s. M., 2017: 24 p. [in Russ.]
  8. Leibovitch E.C., Brunetto G.S., Caruso B. et al. Coinfection of human herpesviruses 6A (HHV-6A) and HHV-6B as demonstrated by novel digital droplet PCR assay. PLoS One. 2014; 9 (3): e92328. doi: 10.1371/journal.pone.0092328.
  9. Heger P.G. Pediatric dermatology. Ed. A.A. Kubanova, A.N. Lvov. Moscow: Panfilov Publishing House; BINOM, 2013: 648 p. [in Russ.]
  10. Sharapova T. N., Romanova E. A., Sashchenko L. P. et al. Tag7 innate immunity protein stimulates the appearance of cytotoxic NK cells after incubation with lymphocytes. Doklady Akademii Nauk. 2019; vol. 484, №6: 777–780. https://doi.org/10.31857/S0869-565248 46777-780. [in Russ.]
  11. Karazhas N.V., Rybalkina T.N., Kalugina M.Yu. et al. Modern aspects of herpesvirus infection. Epidemiology, clinic, diagnosis, treatment and prevention: guidelines. M.: Spetzkniga, 2012: 128 p. [in Russ.]
  12. King O., Al Khalili Y. Herpes Virus Type 6. Treasure Island (FL): StatPearls Publishing; Updated August 8, 2022. Available at: https://www.ncbi.nlm.nih.gov/books/NBK540998/ [Internet].
  13. Agut H., Bonnafous P., Gautheret-Dejean A. Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections. Clin Microbiol Rev.2015; 28 (2): 313–335. doi: 10.1128/CMR.00122-14.
  14. Kharchenko Y, Zaretska A, Broshkov M. The features of the course of infectious mononucleosis of different etiology in children. Georgian Med News. 2019; (287): 51–56.
  15. Demina O.I., Chebotareva T.A., Mazankova L.N. et al. Clinical manifestations of infectious mononucleosis in primary or reactivated herpesvirus infection. Ros vestn perinatol i pediatr 2020; 65 (1): 37–44. doi: 10.21508/1027-4065-2020-65-1-37-44. [in Russ.]
  16. Tyan N.S., Goleva O.V., Babachenko I.V. Clinical and etiological aspects of human beta-herpes virus infection 6. Zhurnal infektologii. 2022; 14 (2): 55–61. doi: 10.22625/2072-6732-2022-14-2-55-64. [in Russ.]
  17. Simonnet A., Engelmann I., Moreau A.S., et al. High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19. Infect Dis Now. 2021; 51 (3): 296–299. doi: 10.1016/j.idnow.2021.01.005
  18. Li J.C. Reactivation of Human Herpesvirus (HHV) 6 as Etiology of Acute Liver Injury in Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Case Report. Cureus. 2022; 14 (9): e29697. doi: 10.7759/cureus.29697.
  19. Fatkullina G.R., Anokhin V.A., Musina A.R. Human herpesvirus type 7 infection in children. Clinical and laboratory aspects. Zhurnal infektologii. 2020; 12 (5): 114–120. doi: 10.22625/2072-6732-2020-12-5-114-122. [in Russ.]
  20. Chencheri N., Dirawi M., Tahir S. et al. The Spectrum of Neurological Manifestations of Human Herpesvirus 6 Infection in Children. Cureus 2021; 13 (8): e17183. doi: 10.7759/cureus.17183.
  21. Komaroff A.L., Pellett P.E., Jacobson S. Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation. Clinical Microbiology Reviews. 2020; 34 (1): e00143-20. doi: 10.1128/CMR.00143-20.
  22. Melekhina E.V., Muzyka A.D., Kalugina M.Yu. et al. Modern ideas about infection caused by human herpes virus type 6. Arkhiv» vnutrenney meditsiny. 2016; 6 (1): 13–19. https://doi.org/10.20514/2226-6704-2016-6-1-13-19 [in Russ.]
  23. Burrel S., Topalis D., Boutolleau D. Herpes simplex virus resistance to antivirals. 2020; 24 (5): 325–342. doi: 10.1684/vir.2020.0864.
  24. Ward K.N., Hill J.A., Hubacek P. et al. Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after hematopoietic stem cell transplantation. Haematologica. 2019; 104 (11): 2155–2163. doi: 10.3324/haematol.2019.223073
  25. HHV-6 Foundation. HHV-6 Treatment. Available at: https://hhv-6foundation.org/clinicians/hhv-6-treatment [Internet]
  26. Flamand L. Chromosomal Integration by Human Herpesviruses 6A and 6B. Adv Exp Med Biol. 2018; 1045: 209–226. doi: 10.1007/978-981-10-7230-7_10.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies