Alcoholic beverages and their effect on the body

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Abstract

Nowadays, the problem of alcohol consumption does not lose its relevance. It is associated with many socio-economic, demographic and health problems. Therefore, it is important to continue research on the effect of alcoholic beverages on organ systems and the body as a whole, ways to prevent alcohol poisoning, study the combination of alcohol with other products, diagnosis and treatment of alcohol poisoning.

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About the authors

Natalia B. Volga

VMed A named after S.M. Kirov

Author for correspondence.
Email: val9126@mail.ru
ORCID iD: 0009-0005-1945-6539
SPIN-code: 7273-4168

Candidate of Medical Sciences, doctor gastroenterologist, Senior lecturer of the 2nd Department of Advanced Medical Training

Russian Federation, St. Petersburg

Irina V. Potapova

VMed A named after S.M. Kirov

Email: val9126@mail.ru
ORCID iD: 0009-0004-6129-1996
SPIN-code: 3685-2664

Candidate of Medical Sciences, Associate Professor of the 2nd Department (Advanced Medical therapy)

Russian Federation, St. Petersburg

Pavel V. Seliverstov

VMed A named after S.M. Kirov

Email: val9126@mail.ru
ORCID iD: 0000-0001-5623-4226
SPIN-code: 6166-7005

Candidate of Medical Sciences, Associate Professor of the 2nd Department (Advanced Medical therapy)

Russian Federation, St. Petersburg

Valery P. Kutsenko

St. Petersburg State Pediatric Medical University Ministry of Health of the Russian Federation

Email: val9126@mail.ru
ORCID iD: 0000-0001-9755-1906
SPIN-code: 5760-0218

Candidate of Medical Sciences, Associate Professor of the Department of Modern Diagnostic Methods and Radiotherapy named after Professor S.A. Reinberg

Russian Federation, St. Petersburg

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Supplementary files

Supplementary Files
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2. Fig. 1. In the Sistine Chapel of the Vatican, frescoes by Michelangelo on a plot from the life of Noah – “The Drunkenness of Noah”.

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3. Fig. 2. Dynamics of changes in state policy regarding water reflected in GOST.

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4. Fig. 3. The mechanism of action of alcohol-containing products on the body.

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5. Fig. 4. The mechanism of the toxic effect of ethyl alcohol.

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6. Fig. 5. Characteristic distribution of ethanol in the lipid membrane at a blood plasma alcohol concentration of 1‰. A portion of the lipids in the upper half of the bilayer is shown. Heavy atoms are indicated in gray, hydrogen atoms in light gray, and oxygen in dark. The upper ethanol molecules (№ 1–4) are in the zone of preferential binding, below which there is an interphase layer of membranes containing proton acceptors. The bottom molecule of ethanol (molecule №5) causes a defect in the ordering of the alkyl tails of the lipid molecules.

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7. Fig. 6. Ethanol metabolism occurs in several stages.

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8. Fig. 7. Ethanol metabolism (from a lecture by Kutsenko V.P. «Private toxicology of «nonelectrolytes»», 2018).

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9. Fig. 8. «Alkо-mushrooms».

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10. Fig. 9. Dose-dependent effects of ethyl alcohol on brain receptors.

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11. Fig. 10. Potassium channel GIRK and its region (red color) with which it interacts ethyl alcohol molecule (yellow).

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12. Fig. 11. Review of the potential role of ethanol and its metabolites at the cellular level in the pathomechanism of psoriasis [4].

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13. Fig. 12. The positive effects of moderate doses of alcohol [2].

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14. Fig. 13. Severity of acute poisoning and clinical manifestations depending on the dosage of ethyl alcohol in the blood.

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15. Fig. 14. Algorithm for providing medical care for alcohol poisoning.

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