Radioprotective properties of natural immunomodulators – ligands of toll-like receptors (Literature review)

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Abstract

Existing radioprotective drugs have serious side effects. Ligands of toll-like receptors (TLRs), which are the one of the primary pattern-recognizing receptors of innate immunity, are considered potentially useful compounds for reducing the toxic effects of radiation exposure. On cell cultures, the radioprotective activity of TLR2, TLR5, or TLR9 receptor agonists has been shown, in particular, the suppression of radiation-induced apoptosis and an increase in cell viability. The drug CBLB502 (TLR5 ligand) contributed to the bone marrow protection and intestinal epithelial cells after irradiation of mice and rhesus monkeys. Activation of TLR4 by its ligand, lipopolysaccharide, reduces bone marrow damage and increases the survival rate of mice. The most promising anti-radiation drugs are agonists of several TLRs – the TLR2/6 co-agonist drug CBLB613 and TLR2/6/4 receptor co-agonists beta-D-glucans. The data on the scientific literature indicate the promise of using TLR ligands as a basis for the new anti-radiation agents development.

About the authors

E. V. Murzina

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Author for correspondence.
Email: elenmurzina@mail.ru

кандидат биологических наук

Russian Federation, Saint Petersburg

N. V. Aksenova

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: elenmurzina@mail.ru

кандидат медицинских наук

Russian Federation, Saint Petersburg

G. A. Sofronov

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: elenmurzina@mail.ru

заслуженный деятель науки РФ, академик РАН, профессор, генерал-майор медицинской службы в отставке

Russian Federation, Saint Petersburg

K. N. Demchenko

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: elenmurzina@mail.ru

кандидат медицинских наук, майор медицинской службы

Russian Federation, Saint Petersburg

A. V. Denisov

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: elenmurzina@mail.ru

кандидат медицинских наук, подполковник медицинской службы

Russian Federation, Saint Petersburg

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Copyright (c) 2023 Murzina E.V., Aksenova N.V., Sofronov G.A., Demchenko K.N., Denisov A.V.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.

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