The effectiveness of the central non-opioid analgesic nefopam in the treatment of acute pain syndrome in participants of a special military operation.
- Authors: Sergoventsev A.A.1, Shchegolev A.V.2, Chuprina A.P.1, Gritsai A.N.2, Arsentiev L.V.2, Aksenfeld D.I.3, Usoltsev E.A.4, Soloviev G.S.5
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Affiliations:
- Main Military Medical Directorate of the Russian Defense Ministry
- The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
- 1602nd Military Clinical Hospital of the Russian Defense Ministry
- 442nd Military Clinical Hospital of the Russian Defense Ministry
- 1472nd Naval Clinical Hospital of the Russian Defense Ministry
- Issue: Vol 345, No 5 (2024)
- Pages: 31-39
- Section: Treatment and prophylactic issues
- URL: https://journals.eco-vector.com/0026-9050/article/view/631484
- DOI: https://doi.org/10.52424/00269050_2024_345_5_31
- ID: 631484
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Abstract
The goal is to evaluate the effectiveness and safety of the use of nefopam in the provision of medical care. The study of the effectiveness of nefopam was carried out in 2 groups: the 1st group (n=53) included patients who, because of dissatisfaction with analgesia, were additionally prescribed a non-steroidal anti-inflammatory drug and trimeperidine at a dose of 20 mg within 30 minutes after the administration of nefopam; Group 2 (n=201) received only nefopam. The administration of nefopam was accompanied by a decrease in pain intensity, normalization of heart rate, and respiratory movements in all 254 patients. The reason for the ineffective relief of pain in group 1 was the development of an initially severe pain syndrome. The likelihood of developing side effects (nausea, vomiting, tremors, sweating, subcutaneous erythema) was 2–9 times lower in group 2. Nefopam is recommended for the relief of pain of moderate intensity; its effectiveness for the relief of severe pain is insufficient.
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About the authors
A. A. Sergoventsev
Main Military Medical Directorate of the Russian Defense Ministry
Email: vmeda-na@mil.ru
заслуженный врач РФ, кандидат медицинских наук, генерал-майор медицинской службы
Russian Federation, MoscowA. V. Shchegolev
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
Email: vmeda-na@mil.ru
профессор, полковник медицинской службы
Russian Federation, St. PetersburgA. P. Chuprina
Main Military Medical Directorate of the Russian Defense Ministry
Email: vmeda-na@mil.ru
доцент, полковник медицинской службы
Russian Federation, MoscowA. N. Gritsai
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
Author for correspondence.
Email: vmeda-na@mil.ru
кандидат медицинских наук, полковник медицинской службы
Russian Federation, St. PetersburgL. V. Arsentiev
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
Email: vmeda-na@mil.ru
кандидат медицинских наук, подполковник медицинской службы
Russian Federation, St. PetersburgD. I. Aksenfeld
1602nd Military Clinical Hospital of the Russian Defense Ministry
Email: vmeda-na@mil.ru
подполковник медицинской службы
Russian Federation, Rostov-on-DonE. A. Usoltsev
442nd Military Clinical Hospital of the Russian Defense Ministry
Email: vmeda-na@mil.ru
подполковник медицинской службы
Russian Federation, St. PetersburgG. S. Soloviev
1472nd Naval Clinical Hospital of the Russian Defense Ministry
Email: vmeda-na@mil.ru
подполковник медицинской служб
Russian Federation, SevastopolReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).