New coronavirus infection COVID-19, complicated by the development of rapidly progressive glomerulonephritis

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Abstract

The first in Russia description of a clinical observation of a new coronavirus infection (COVID-19), which was complicated by the development of severe lung damage, rapidly progressive glomerulonephritis with the formation of antibodies to the glomerular basement membrane, polyserositis (hydrothorax, hydropericardium, ascites), dilatation of the heart cavities, hepatolienal syndrome, anemia of mixed genesis (nephrogenic, iron deficiency) of moderate severity is given. The pathophysiological features of multiple organ pathology in a patient with COVID-19 and kidney disease are discussed. The role of the systemic inflammatory response syndrome resulting from the cytokine storm is emphasized. The issues of complex examination, differential diagnostics and specialized treatment are reflected. Taking into account the multisystem nature of the lesion and the development of post-COVID complications, patients should be under the dispensary and dynamic registration of a multidisciplinary team of doctors (therapist, nephrologist, pulmonologist, cardiologist, gastroenterologist, hematologist) for a long time (at least 9 months) with comprehensive monitoring of the function of the kidneys, lungs, heart, other organs and systems, with renal replacement therapy, which improves the prognosis of the life of such patients.

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About the authors

V. V. Navaznov

National Medical Research Center for High Medical Technologies – The A.A.Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Author for correspondence.
Email: 3hospital@mil.ru

подполковник медицинской службы запаса

Russian Federation, Krasnogorsk, Moscow Region

E. S. Tasoeva

National Medical Research Center for High Medical Technologies – The A.A.Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Email: 3hospital@mil.ru
Russian Federation, Krasnogorsk, Moscow Region

S. N. Karpova

National Medical Research Center for High Medical Technologies – The A.A.Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Email: 3hospital@mil.ru
Russian Federation, Krasnogorsk, Moscow Region

A. I. Pavlov

National Medical Research Center for High Medical Technologies – The A.A.Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation; Russian Biotechnological University (ROSBIOTECH)

Email: 3hospital@mil.ru

заслуженный врач РФ, доктор медицинских наук, полковник медицинской службы

Russian Federation, Krasnogorsk, Moscow Region; Moscow

A. A. Prokhorchik

National Medical Research Center for High Medical Technologies – The A.A.Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation; Branch of the S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: 3hospital@mil.ru

заслуженный врач РФ, кандидат медицинских наук, полковник медицинской службы

Russian Federation, Krasnogorsk, Moscow Region; Moscow

N. I. Gulyaev

National Medical Research Center for High Medical Technologies – The A.A.Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation; Branch of the S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: 3hospital@mil.ru

доктор медицинских наук, полковник медицинской службы

Russian Federation, Krasnogorsk, Moscow Region; Moscow

V. I. Baksheev

National Medical Research Center for High Medical Technologies – The A.A.Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Email: 3hospital@mil.ru

лауреат Государственной премии РФ им. Г.К.Жукова, заслуженный врач РФ, доктор медицинских наук, полковник медицинской службы в отставке

Russian Federation, Krasnogorsk, Moscow Region

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2. Nephrobiopsy of patient B., 46 years old: A - glomeruli with segmental and circular fibrous crescents. The glomerulus without crescents looks little changed. Coloring CHIC reaction. Ch100. B - linear glow of IgG at the periphery of capillary loops (immunoflorescent study)

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Copyright (c) 2024 Navaznov V.V., Tasoeva E.S., Karpova S.N., Pavlov A.I., Prokhorchik A.A., Gulyaev N.I., Baksheev V.I.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.

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