Сell engineering in the treatment of diabetes mellitus: current state and prospectives


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The article is dedicated to the current state and prospectives of cell engineering in the treatment of diabetes mellitus. The material is based on the analysis of clinical trials in which cell engineering has been applied for the treatment of diabetes mellitus and its complications. It has been shown that despite the decade of intensive research the clinically significant results have not been achieved yet. At the same time the fast growth of the number of publications in the field testified to intensity of basic and applied research and the large quantity of ongoing clinical trials on the topic make it possible to look at the prospectives of the employment of cell engineering in the treatment of diabetes mellitus with a certain optimism.

Full Text

Restricted Access

References

  1. (Diabetes[Title/Abstract]) AND Stem [Title/Abstract] // PubMed. URL: http://www. ncbi.nlm.nih.gov/pubmed?term=%28 Diabetes[Title%2FAbstract]%29%20AND% 20Stem[Title%2FAbstract] (дата обращения: 01.01.2016).
  2. Autologus Hematopoietic Stem Cell Transplant in Type 1 Diabetes Mellitus in a Nonmyeloablative and Outpatient Setting / Cantu-Rodriguez O.G. et al. // The 56th Annual Meeting of the American Society of Hematology, San Francisco, California. December 6-9, 2014. HTML. URL: https://ash.confex.com/ash/2014/webprogram/Paper75849.html (дата обращения: 01.01.2016).
  3. studies found for: Recruiting | Exclude Unknown | Diabetes | Stem cells // ClinicalTrials.gov. URL: https://clinicaltrials.gov/ct2results?term=&recr=Open&no_unk=Y&rslt=&t ype=&cond=Diabetes&intr=Stem+cells&titles= &outc=&spons=&lead=&id=&state1=&cntry1=&st ate2=&cntry2=&state3=&cntry3=&locn=&gndr=& rcv_s=&rcv_e=&lup_s=&lup_e= (дата обращения: 01.01.2016).
  4. Angiographic demonstration of neoangiogenesis after intra-arterial infusion of autologous bone marrow mononuclear cells in diabetic patients with critical limb ischemia / Ruiz-Salmeron R. et al. // Cell Transplant. 2011. Vol. 20, N 10. P. 1629-1639. PDF. URL: http://www. kumc.edu/Documents/msctc/Ruiz-Salmeron.pdf (дата обращения: 01.01.2016).
  5. Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients / Kirana S. et al. // Int J Clin Pract. 2012. Vol. 66, N 4. P. 384-393. PDF. URL: http://www.kumc.edu/Dokuments/msctc/Kirana.pdf (дата обращения: 15.03.2016).
  6. Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes / Haller M.J. et al. // Biol Blood Marrow Transplant. 2013. Vol. 19, N 7. P. 1126-1129. PDF. URL: http://www.ncbi.nlm. nih.gov/pmc/articles/PMC3852705/pdf/nihms 529410.pdf (дата обращения: 01.01.2016).
  7. Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer / Prochazka V. et al. // Cell Transplant. 2010. Vol. 19, N 11. P. 1413-1424. PDF. URL: https://www.researchgate.net/profile/Jaromir_Gumulec2/publication/44655240_Cell_therapy_a_new_ standard_in _management_of_chronic_critical_ limb_ischemia_and_foot_ulcer/links/00b7 d52f79cc0e5056000000.pdf (дата обращения: 01.01.2016).
  8. ClinicalTrials.gov. The Official Web Site. URL: https://clinicaltrials.gov/ct2/home (дата обращения: 01.01.2016).
  9. Insulin pump therapy, multiple daily injections, and cardiovascular mortality in 18168 people with type 1 diabetes: observational study/ Steineck I. et al. // BMJ. 2015. Vol. 350:h3234. 9 p.PDF. URL: http://www.bmj.com/content/bmj/350/bmj.h3234. full.pdf (дата обращения: 01.01.2016).
  10. Matveyenko A., Vella A. Regenerative Medicine in Diabetes // Mayo Clin Proc. 2015. Vol. 90, N 4. P. 546-554. PDF. URL: http://www. mayo clinicproceedings.org/article/S0025-6196%2815% 2900107-X/pdf (дата обращения: 01.01.2016).
  11. Preserved b-cell function in type 1 diabetes by mesenchymal stromal cells / Carlsson P.O. et al. // Diabetes. 2015. Vol. 64, N 2. P. 587-592. HTML. URL: http://diabetes.diabetesjournals.org/content/64/2/587.long (дата обращения: 01.01.2016).
  12. Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial / Zhao Y. et al. // BMC Med. 2013. Vol. 11. Art 160. PDF. URL: http://www.biomedcentral.com/content/pdf/1741-7015-11-160.pdf (дата обращения: 01.01.2016).

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Nagibovich O.A., Golota A.S., Krassii A.B.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.