Effectiveness and safety of antiviral therapy of military personnel suffering from chronic hepatitis C

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

In order to evaluate effectiveness and safety of antiviral therapy schemes examined and treated 191 patients with chronic hepatitis C were assigned standard interferon and ribavirin, pegs-lated interferon and ribavirin, the total duration of the course coput 24-48 weeks. Based on clinical and laboratory parameters evaluated the safety of antiviral therapy. Formation of sustainable viral response, depending on the genotype observed, was given at 58,9-70% of patients. In case of insufficient antiviral therapy was prescribed a second course that will improve the effectiveness of treatment to 90-95%. Correction of adverse events was held lower dosages of interferon and/or ribavirin.

Full Text

Restricted Access

References

  1. Жданов К.В., Лобзин Ю.В., Гусев Д.А., Козлов К.В. Вирусные гепатиты. - СПб: Фолиант, 2011. - 304 с.
  2. Жданов К.В., Гусев Д.А., Козлов К.В. и др. Организация медицинской помощи военнослужащим, больным хроническими вирусными гепатитами, в Вооруженных Силах РФ // Журнал инфектологии. - 2012. - Т. 4, № 4. - С. 90-97.
  3. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. - М.: МедиаСфера, 2006. - 305 с.
  4. Coppola N., Pisaturo M., Sagnelli C. et al. Peg-Interferon Plus Ribavirin with or without Boceprevir or Telaprevir for HCV Genotype 1: A Meta-Analysis on the Role of Response Predictors // PLoS One. - 2014. - Vol. 9, N 4. - P. 94542.
  5. Mauss S., Berg T., Rockstroh J. et al. (eds). Hepatology. A Clinical Textbook. - 2015. - 612 p. URL: www. flyingpublisher.com (дата обращения: 28.02.2015).
  6. Zeuzem S., Pawlotsky J.M., Lukasiewicz E. et al. International, multicenter, randomized, controlled study comparing dynamically individualized versus standard treatment in patients with chronic hepatitis C // J. Hepatol. - 2005. - Vol. 43, N 2. - P. 250-257.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2015 Zhdanov K.V., Gusev D.A., Kozlov K.V., Shishkin M.K., Sukachev V.S., Shakhmanov D.M., Zhabrov S.S.



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies