Ebola virus disease: clinical and diagnostic aspects and organization of treatment-and-prophylactic measures


Cite item

Full Text

Abstract

The article presents data about world spread of Ebola virus disease, biological characteristics of the pathogen, the laws of the epidemic process in this disease, its pathogenesis, clinical manifestations and diagnosis. Pointed out that the current anti-viral agents, effective for the Ebola virus, have not been developed. Timely performed pathogenetic therapy improves the prognosis of the disease. The basis of this therapy is infusion-detoxiflcation activities and replenishment of losses of electrolytes, as well as anti-inflammatory and anti-emetic drugs. The Armed Forces of the Russian Federation received the guidelines for preventive measure that can reduce Ebola virus disease transmission. Recommendations for emergency anti-epidemic commission consisted of representatives of the command, specialists and medical services and logistics, are given. Fundamentally important condition for the effective anti-epidemic measures is not only the constant readiness of medical personnel in the detection of disease EVD,but also the appropriate level of equipment of medical institutions of medical supplies and equipment.

Full Text

Restricted Access

References

  1. Международные медико-санитарные правила (2005) / Второе издание. - Женева: ВОЗ, 2008. - 82 с. URL: http://whqlibdoc.who.int/publications/2008/9789244580417_rus.pdf (дата обращения: 30.10.2014).
  2. Приказ Министра обороны Российской Федерации № 2552 от 31.08.2012 г. «Об обеспечении санитарно-эпидемиологического благополучия в Вооруженных Силах Российской Федерации». URL: http://www.base.garant.ru (дата обращения: 14.10.2014).
  3. Рекомендации Роспотребнадзора для медицинских работников по геморрагической лихорадке Эбола от 01.04.2014 г. № 01/361714-32. URL: http://www.docs.int.ru (дата обращения : 14.10.2014).
  4. Санитарно-эпидемиологические правила СП 3.4.2318-08 «Санитарная охрана территории Российской Федерации». URL: http://www.base.garant.ru (дата обращения: 14.10.2014).
  5. Федеральный закон «О санитарно-эпидемиологическом благополучии населения» от 30 марта 1999 года № 52-ФЗ. URL: http://www.base.garant.ru (дата обращения: 14.10.2014).
  6. Borchert M., Mutyaba I., Van Kerkhove M.D. et al. Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned // BMC Infect Dis. - 2011. - N 11. - P. 357.
  7. Briand S., Bertherat E., Cox P. et al. The international Ebola emergency // N. Engl. J. Med. - 2014. - Vol. 371. - P. 1180-1183.
  8. Ebola and Marburg virus disease epidemics: preparedness, alert, control, and evaluation / INTERIM version 1.2. - Geneva: WHO. - 2014. - 123 p. URL: http://www.aselem.org (дата обращения: 14.10.2014).
  9. Ebola haemorrhagic fever in Zaire, 1976 / Report of an International Commission // Bull. of WHO. - 1978. - Vol. 56, N 2. - P. 271-293.
  10. Ebola Virus Disease in West Africa. The First 9 Months of the Epidemic and Forward Projections / WHO Ebola Response Team. -September 23, 2014. URL: http://www.NEJM.org (дата обращения: 14.10.2014).
  11. Ebola virus disease. Fact sheet N103. -WHO. - 01. 03. 2014. Updated September 2014. URL: http://www.who.int (дата обращения: 14.10.2014).
  12. Feldmann H., Geisbert T.W. Ebola haemorrhagic fever // The Lancet. - 2011. - Vol. 377, Issue 9768. - P. 849-862.
  13. Gire S.K., Goba A., Andersen KG. et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak // Science. - 2014. - N 345. - P. 1369-1372.
  14. Nanbo A., Watanabe S., Halfmann P., Kawaoka Y. The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells // Scientific Reports. - 2013. - N 3. - Article number: 1206.
  15. O’Brien L.M., Stokes M.G., Lonsdale S.G. et al. Vaccination with recombinant adenoviruses expressing Ebola virus glycoprotein elicits protection in the interferon alpha/beta receptor knock-out mouse // Virology. - 2014. - N 452453. - P. 324-333.
  16. Oestereich L., Lüdtke A., Wurr S. et al. Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model // Antiviral Research. - 2014. -N 105. - P. 17-21.
  17. Rim K.-T., Lim C.-H. Biologically Hazardous Agents at Work and Efforts to Protect Workers’ Health: A Review of Recent Reports // Safety and Health at Work. - 2014. - N 5. -P. 43-52.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2014 Fisun A.Y., Zhdanov K.V., Zakharenko S.M., Kovalenko A.N.



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies