Methods of evaluation of efficiency of laboratory animals in the experimental influence of pathogenic and extreme factors

Abstract

In the experimental study of various environmental factors that negatively impact on the functional state of the organism of military, an important component is the assessment of performance. To this end, studies in laboratory settings that simulate the main types of human actions — mainly physical or mainly mental. In the described complex techniques used to simulate the performance of separate elements of the targeted actions of a man in experiments in small (mice, rats) and large (dogs, monkeys) laboratory animals under the effect of investigated factors. As a result of this approach, obtained in experiments with complex methodologies formed a dose-time dependence of efficiency of animals may be used, taking into account interspecies extrapolation regularities as a rapid assessment for predicting effects in humans from exposure to adverse factors studied.