Polymorphisms of the BDNF (rs6265) and LIPC (rs2043085) genes associated with the violation of military professional activity in the Arctic zone

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

The association of polymorphisms of 8 different genes with the pathology of the nervous and cardiovascular systems of military personnel serving in the Arctic zone was studied. It has been shown that military personnel with the G/G genotype (G/A polymorphism – rs6265 in the brain-derived neurotrophic factor BDNF gene) in combination with the C/C genotype (T/C polymorphism – rs2043085 of the LIPC gene) are recommended for service in the Arctic belt. Ceteris paribus, it is preferable that the genotype of officers serving in the Arctic zone be G/G for the BDNF gene and C/C for the LIPC gene (rs6265 and rs2043085 polymorphisms, respectively). From a prognostic point of view, the selection criteria for military personnel by genotypes will increase the combat capabilities of groupings of troops (forces) in the Arctic zone of Russia.

作者简介

A. Lemeshchenko

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

编辑信件的主要联系方式.
Email: lav_1981@mail.ru

кандидат медицинских наук, подполковник медицинской службы

俄罗斯联邦, Saint Petersburg

V. Tsygan

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: lav_1981@mail.ru

заслуженный деятель науки РФ, профессор, полковник медицинской службы в отставке

俄罗斯联邦, Saint Petersburg

E. Kazakova

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: lav_1981@mail.ru

кандидат биологических наук

俄罗斯联邦, Saint Petersburg

参考

  1. Запесочная И.Л., Автандилов А.Г. Проблема адаптации сердечно-сосудистой системы при проживании на Крайнем Севере: Учеб. пособие. – М.: ГБОУ ДПО РМАПО, 2015. – 127 с.
  2. Ким А.Е., Шустов Е.Б., Лемещенко А.В., Цыган В.Н. Патофизиологические основы формирования дезадаптаций в условиях высокогорья и полярных зон // Вестн. Рос. воен.-мед. акад. – 2021. – № 3 (75). – C. 215–222.
  3. Турчинский В.И. Ишемическая болезнь сердца на Крайнем Севере. – Новосибирск: Наука, 1980. – 281 с.
  4. Шестов А.В., Иванов Б.А., Бирюков М.А. Взаимосвязь показателей функционального состояния и работоспособности военнослужащих в процессе лыжного марша к Северному полюсу // Учен. записки ун-та им. П.Ф.Лесгафта. – 2017. – Т. 12, № 154. – С. 311–316.
  5. Andrеs-Blasco I., Vinuе А., Herrero-Cervera A. et al. Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin в-Receptor pathway // Thromb. Haemost. – 2016. – Vol. 116, N 2. – P. 379–393.
  6. Cabrera S., Benavente D., Alvo M. et al. Vitamin B12 deficiency is associated with geographical latitude and solar radiation in the older population // J. Photochem. Photobiol. B. – 2014. – Vol. 140, Is. 2. – P. 8–13.
  7. Elston R.C. Communication and association // Genet. Epidemiol. – 1998. – Vol. 15, N 6. – P. 565–576. doi: 10.1002/(SICI)1098-2272(1998)15:6<565::AND-GAPE2>3.0.CO;2-J
  8. Gonzalez A., Moya-Alvarado G., Gonzalez-Billo K., Bronfman F.C. Cellular and molecular mechanisms regulating the growth of neurons with the help of brain neurotrophic factor // Cytoskeleton (Hoboken). – 2016. – Vol. 73, N 10. – P. 612–628.
  9. Hennis P.J., Doherty A.F., Leavitt D.Z. et al. Genetic factors associated with physical activity in atmospheric hypoxia // Sports medicine. – 2015. – Vol. 45, Is. 5. – P. 456–461.
  10. Jones A., Montgomery H.E., Woods D.R. Human Performance: The Role of the ACE Genotype? // Exercise and Sports Sci. Rev. – 2002. – Vol. 30, Is. 4. – Р. 184–190.
  11. Lander E.S. Shork New Jersey. Genetic dissection of complex features // The Science. – 1994. – Vol. 265. – P. 2037–2048. doi: 10.1126/science.8091226
  12. Lasalle F., Alarcon M., Solomon E.K. et al. Association of serotonin transporter gene and receptor polymorphisms in neuropsychiatric symptoms in Alzheimer’s disease // Arch. Neurol. – 2004. – Vol. 61, N 8. – P. 1249–1253.
  13. Malchinskaya P., Petrovich Z., Drabarek D. et al. The role of brain neurotrophic factor (BDNF) in neurodegenerative processes and in the mechanisms of neuroregeneration induced by increased physical activity // Postepi Biochem. – 2019. – Vol. 65, N 1. – P. 2–8.
  14. Polesskaya O.O., Sokolov B. Differential expression of alleles «C» and «T» of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics // J. Neurosci. Res. – 2002. – Vol. 61, N 8. – P. 812–822.
  15. Sharovich C.A., Steece-Collier K., Caulfield M.E. New frontiers in neurodegeneration and regeneration associated with brain neurotrophic factor and single nucleotide polymorphism rs6265 // Int. J. Mol. Sci. – 2022. – Vol. 23, N 14. – P. 8011.
  16. Rich D.Q., Gaziano J.M., Kurth T. Geographic patterns in overall and specific cardiovascular disease incidence in apparently healthy men in the United States // Stroke. – 2007. – Vol. 38, Is. 8. – P. 2221–2227.
  17. Teng M.S., Wu S., Hsu L.A. et al. Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population // Lipids Health. – 2019. – Vol. 18. – P. 111.
  18. Thomson G. Mapping disease genes: family associative studies // Am. J. Hum. Genet. – 1995. – Vol. 57, N 2. – P. 487–498.
  19. Thomson G., Esposito M.S. Genetics of complex diseases // Trends Cellular Biol. – 1999. – Vol. 9, N 12. – P. 17–20.
  20. Brown R.J., Gauthier A., Parks R.J. et al. Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase with a deficiency of heparan sulfate binding to proteoglycan // J. Biol. Chem. – 2004. – Vol. 279, N 41. – P. 42403–42409. doi: 10.1074/jbc. M407748200
  21. https://www.ncbi.nlm.nih.gov/snp/ (дата обращения: 16.05.2020).

补充文件

附件文件
动作
1. JATS XML

版权所有 © Lemeshchenko A.V., Tsygan V.N., Kazakova E.A., 2023



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.
##common.cookie##