卷 30, 编号 5 (2019)

The paper reviews the foreign literature that gives an idea of compliance in liver transplant recipients, its level, and study methods. The data from different transplant centers on compliance in liver transplant recipients are contradictory (from 3 to 99%). Low treatment adherence in liver transplant recipients correlates with a substantial increase in late acute rejection, graft loss, and death. Possible reasons for inconsistency of data on compliance in these patients are considered.

The paper evaluates and compares the efficacy and toxicity of drugs based on iron (III)- hydroxide polymaltose complex and iron (II) sulfate given in standard doses for the treatment of iron-deficiency anemia in children.

Peri-and postmenopausal women may develop the clinical and functional signs of dry eye syndrome (DES), which vary in severity. They are most significant in patients with severe menopausal syndrome (MS) and conform to severe DES. The signs of mild DES are accordingly observed in mild MS. In all the patients, DES is manifested chiefly by subjective symptoms according to the severity of MS. The treatment and prevention of DES in peri- and postmenapausal women are considered.

The features of cellular immunity in the blood of patients with atrophic body gastritis were investigated. A comparative study was conducted in 85 patients with moderate atrophic body gastritis, 25 patients with severe atrophic body gastritis, and 90 apparently healthy people at the age of 25 to 65 years who were examined. Atrophic gastritis was diagnosed, by determining serum pepsinogen-1 and pepsinogen-2 levels and morphologically examining the gastric mucosa. Cellular immunity in the blood was estimated by indirect immunofluorescence assay using monoclonal antibodies (CD3, CD4, CD8, and CD16). The serum concentration of immunoglobulins A, M, E, and G was determined by enzyme immunoassay. Patients with severe atrophic body gastritis were found to have lower levels of T lymphocytes, T helper cell subpopulations, blood CD4+/CD8+ ratios and IgA and IgG concentrations than healthy individuals. There were signs of secondary immunodeficiency manifested as a decrease in the T helper cell lymphocytes, a secondary humoral immune response, and local protection in patients with severe atrophic body gastritis as compared to the control group.

The paper analyzes age and gender characteristics, clinical symptoms, and medical history data in patients with gastric polyps. The incidence of adenomatous polyps is higher in men and in their localization in the gastric antrum.

Hemophilia B is one of the inherited coagulopathies associated with coagulation factor IX deficiency. If there is a need for surgical treatment, patients receive replacement therapy with drugs containing IX coagulation factor. In the Russian Federation, there is a state program «Development of the Pharmaceutical and Medical Industry» for 2013-2020, aimed at increasing the production and availability of Russian vital and essential medicines, including those for the treatment of hemophilia A and B. A clinical example of the effective use of recombinant coagulation factor IX (Innonafactor, nonacog alfa, AO «GENERIUM») is described for the first time in the surgical treatment of closed right humeral mid-shaft fracture with displaced fragments in a patient with severe hemophilia B.

A clinical and economic analysis of the complex effects of magnetic therapy was carried out in patients with low back pain in a healthcare facility.

The paper considers obstetric tactics for fetal arrhythmias and minor fetal cardiac malformations. It characterizes perinatal outcomes in this pathology of the fetus. Options for improving perinatal outcomes are proposed.

The diagnostic efficacy of abdominal laparoscopy and ultrasonography was retrospectively in patients who had been hospitalized with a diagnosis of acute appendicitis. Only laparoscopy was used in the period of 2001 to 2003; laparoscopy and ultrasonography were performed in 2015 to 2017. It was shown that the quality of prehospital diagnosis of acute appendicitis became worse; the use of abdominal ultrasonography could reduce the number of laparoscopies from 26.1 to 6.8% (p < 0.05).