OPYT PRIMENENIYa «MYaGKIKh» SKhEM STIMULYaTsII SUPEROVULYaTsII U PATsIENTOK GRUPPY RISKA RAZVITIYa SINDROMA GIPERSTIMULYaTsIIYaIChNIKOV
- Authors: Kalinina EA1, Ebzeeva MV1, Kuz'michev LN1, Kalinina Y.A1, Ebzeyeva MV1, Kuzmichev LN1
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Affiliations:
- Issue: No 6 (2010)
- Pages: 60-64
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246388
- ID: 246388
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Abstract
The paper presents the results of a study to enhance the efficiency and safety of in vitro fertilization (IVF) programs in patients at high risk for ovarian hyperstimulation syndrome (OHSS), by applying the modified protocols. In 50 study group patients, the ovaries were stimulated by the mild regimen using low-dose (75-150 IU) recombinant follicle-stimulating hormone (rFSH) from day 5 of their menstrual cycle; in a control group comprising 25 patients, the IVF program was implemented by a short protocol from day 2-3 of their menstrual cycle, by administering the standard doses of rFSH (150-225 IU). The daily and course doses of the inductor, the number of growing and dominant follicles, obtained oocytes and embryos, their quality, and the incidence rates of OHSS were estimated.
The number of growing follicles was 9.2±1.8 and 12.2±2.4 in the study and control groups, respectively; the daily dose of the inductor was 125.5±45.7 and 175±25.8 IU; its course dose was 950±157.4 and 1405±178.2 IU; the obtained oocytes averaged 7.5±1.2 and 12.1±1.3; the fertilization rate was 65.1 and 78.5%; pregnancy occurred in 22.8 and 28.3% of cases, respectively; embryo transfer had to be cancelled due to a risk for OHSS in 8 and 12% of the patients, respectively.
It is expedient to use mild superovulation regimens in OHSS-risk group patients.
The number of growing follicles was 9.2±1.8 and 12.2±2.4 in the study and control groups, respectively; the daily dose of the inductor was 125.5±45.7 and 175±25.8 IU; its course dose was 950±157.4 and 1405±178.2 IU; the obtained oocytes averaged 7.5±1.2 and 12.1±1.3; the fertilization rate was 65.1 and 78.5%; pregnancy occurred in 22.8 and 28.3% of cases, respectively; embryo transfer had to be cancelled due to a risk for OHSS in 8 and 12% of the patients, respectively.
It is expedient to use mild superovulation regimens in OHSS-risk group patients.
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