ESTIMATION OF BLOOD RHEOLOGICAL PARAMETERS IN PREGNANT WOMEN WITH PLACENTAL INSUFFICIENCY AFTER IN VITRO FERTILIZATION, BY USING PLASMAPHERESIS
- Authors: BURANOVA F.B1, FEDOROVA T.A1, KIRYUSHCHENKOV P.A1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- Issue: No 3 (2012)
- Pages: 37-43
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246691
- ID: 246691
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Abstract
Objective. To evaluate the impact of plasmapheresis (PA) on blood rheological parameters in pregnant women with placental insufficiency (PI) after in vitro fertilization (IVF). Subjects and methods. One hundred and five pregnant women with PI were examined after IVF; in 28 of them blood rheological parameters were studied before, during, and after termination of a course of therapy, the results of which were compared with those in 15 control pregnant women. When estimating the hemostatic parameters, the authors considered fibrinogen concentration, activated partial thromboplastin time, activated recalcification time, as well as thromboelastography readings by chronometric (r + k) and structural (ma) coagulation parameters, and thrombodynamic potential index. Blood rheological parameters were estimated by macrorheological (asymptomatic blood viscosity, plasma viscosity, packed cell volume, and plasma total fibrinogen concentration) and microrheologic (spontaneous red blood cell aggregation and disaggregation) parameters. Results. After IVF, the abnormal parameters of the plasma hemostatic system and blood rheology in pregnant women with PI are largely due to those in microrheology, which is associated with the processes of impaired aggregation, disaggregation, deformity of red blood cells, and increased formation of their linear aggregates. Unlike conventional therapy, PA using 6% hydroxyethyl starch in the treatment of pregnant women with PI after IVF improved plasma hemostatic and blood microrheological parameters. Conclusion. Incorporation of remedial PA into the combined therapy for PI in pregnant women after IVF could achieve normal blood clotting potential, better blood rheological parameters, and longer pregnancy until optimal labor happens.
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About the authors
F. B BURANOVA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: bfbdoctor@gmail.com
Moscow
T. A FEDOROVA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of RussiaMoscow
P. A KIRYUSHCHENKOV
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of RussiaMoscow
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