Approaches to producing, purifying, and standardizing polyprenols
- Authors: Antipina A.A1, Balabaniyan V.Y.1
-
Affiliations:
- M.V. Lomonosov Moscow State University
- Issue: Vol 70, No 6 (2021)
- Pages: 15-19
- Section: Articles
- URL: https://journals.eco-vector.com/0367-3014/article/view/113563
- DOI: https://doi.org/10.29296/25419218-2021-06-03
- ID: 113563
Cite item
Abstract
Polyprenols are an original class of natural compounds, the unique chemical structure of which determines a diversity of their biological properties and a wide spectrum of pharmacological activities. As oligosaccharide donors in the protein N-glycosylation process, polyprenols are directly involved in the synthesis of cell membrane glycoproteins, which contributes to the acceleration of cell regeneration and renewal. Due to their chemical structure, polyprenols act as fat-soluble antioxidants, by suppressing oxidative stress. In addition, polyprenols stimulate metabolic processes and increase the viability of cells, by enhancing the fluidity and permeability of their biological membranes. At the moment, Russia has registered the only drug based on polyprenols, which is a hepatoprotector. Other types of pharmacological activity of polyprenols have been also studied; the latter were observed to have neuroprotective, anti-inflammatory, antitumor, antibacterial, and other pharmacological activities. The design of new medicines based on polyprenols is of particular scientific and practical interest. The most common sources of polyprenols are the foliage on the coniferous trees (various species of fir, abies, and pine) and the leaves of Ginkgobiloba. Polyprenols are isolated from medicinal plant raw materials through extraction that is based on the solubility difference in two or more organic solvents. Other methods for obtaining polyprenols, such as supercritical carbon dioxide extraction or extraction with deep eutectic solvents, are also known. The main method for the standardization of polyprenols is high-performance liquid chromatography. Polyprenols may be analyzed using electrospray ionization mass spectrometry, atmospheric pressure photoionization mass spectrometry, and matrix-activated laser desorption/ionization time-of-flight mass spectrometry.
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About the authors
A. A Antipina
M.V. Lomonosov Moscow State University
Email: antipina_aa@rambler.ru
1, Leninskie Gory, Moscow 119991, Russian Federation
V. Yu Balabaniyan
M.V. Lomonosov Moscow State University
Email: bal.pharm@mail.ru
1, Leninskie Gory, Moscow 119991, Russian Federation
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