Antihistamines of the 2nd and 3rd generation in Russia

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Abstract

Introduction. Antihistamines play an important role in the treatment of allergic diseases, which are becoming more common in metropolitan areas. Currently, more and more patients are turning to specialists with symptoms of allergic rhinitis. According to the clinical guidelines for the treatment of allergic rhinitis, approved in 2024 and revised no later than 2026, all patients with allergic rhinitis are recommended to prescribe systemic antihistamines without sedation in order to reduce itching in the nasal cavity, sneezing, rhinorrhea, and nasal congestion:

  • Desloratadine (ATC code: R06AX27);
  • Levocetirizine (ATC code: R06AE09);
  • Loratadine** (ATC code: R06AX13);
  • Cetirizine** (ATC code: R06AE07);

The purpose of this study is to compare antihistamine drugs (drugs) of different generations according to the following criteria: the range of prescriptions according to ICD-10, adverse reactions during use, the range of these drugs; to study the trend of demand and seasonality.

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About the authors

Olga Valerievna Krylova

Sechenov First Moscow State Medical University

Email: krylova_o_v@staff.sechenov.ru
ORCID iD: 0000-0002-0552-639X

Associate Professor at the Department of Pharmacy of the Nelyubin Institute of Pharmacy

Russian Federation, Moscow

Elsa Ruslanovna Mamontova

Pirogov Russian National Research Medical University

Email: elza.mamontova@mail.ru
ORCID iD: 0000-0001-8199-2053

Associate Professor at the Department of Pharmacy of the Institute of Pharmacy and Medicinal Chemistry

Russian Federation, Moscow

Sevara Dzhurabekovna Marchenko

Sechenov First Moscow State Medical University

Email: marchenko_s_d@staff.sechenov.ru
ORCID iD: 0000-0002-0177-6826

Associate Professor at the Department of Organization and Management in the Field of Drug Circulation of the Institute of Professional Education

Russian Federation, Moscow

Maria Vladislavovna Radushnova

Sechenov First Moscow State Medical University

Email: masharadushnova@list.ru
ORCID iD: 0009-0004-3722-6756

5th-Year Student at the Nelyubin Institute of Pharmacy

Russian Federation, Moscow

Nikita Grigorievich Paskar

Sechenov First Moscow State Medical University

Author for correspondence.
Email: nnikpaskar@yandex.ru
ORCID iD: 0009-0002-6656-6667

5th-Year Student at the Nelyubin Institute of Pharmacy

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. The ratio of the number of registered antihistamines by international nonproprietary name

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3. Fig. 2. Analysis of sales of antihistamine drugs for the period from January 2021 to December 2023

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4. Fig. 3. Sales of antihistamine drugs of the 2nd and 3rd generations

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5. Fig. 4. Dynamics of sales of medicines under the international nonproprietary name loratadine in the period from January 2021 to December 2023

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6. Fig. 5. Dynamics of sales of drugs under the international nonproprietary name desloratadine in the period from January 2021 to December 2023

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7. Fig. 6. Dynamics of sales of medicines under the international nonproprietary name cetirizine in the period from January 2021 to December 2023

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8. Fig. 7. Dynamics of sales of medicines under the international nonproprietary name levocetirizine in the period from January 2021 to December 2023

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