Prospects for developing dietary supplements with taxifolin and andrographolide
- Authors: Potupchik T.V.1, Ananyan M.A.2, Stepanov M.R.2, Paskar N.G.3, Khaustova S.Y.4
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Affiliations:
- Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky” of the Ministry of Health of the Russian Federation
- Advanced Technologies LLC
- I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
- Synergy University (Moscow University "Synergy")
- Issue: Vol 74, No 4 (2025)
- Pages: 31-37
- Section: Pharmaceutical chemistry and pharmacognosy
- URL: https://journals.eco-vector.com/0367-3014/article/view/686289
- DOI: https://doi.org/10.29296/25419218-2025-04-04
- ID: 686289
Cite item
Abstract
Introduction. Psoriasis is a chronic immunoinflammatory skin disease with a prevalence of about 2% among the population, characterized by immune system imbalance and excessive production of proinflammatory cytokines. Standard therapy is effective but limited by side effects, creating a need for new safe approaches.
Objective: theoretical substantiation of the prospects of combining taxifolin and andrographolide in a gel formulation for adjunctive psoriasis therapy based on analysis of current data on molecular targets of each component.
Material and methods. Analysis of current publications in PubMed, Scopus, eLibrary databases using keywords: taxifolin, andrographolide, psoriasis, inflammation, NF-κB, IL-17. Mechanisms of action at cellular and molecular levels, in vitro and in vivo study data were reviewed.
Results. Taxifolin primarily modulates inflammatory cascades in keratinocytes through NF-κB/STAT3 blockade, reducing IL-6, IL-8, CCL20 production. Andrographolide affects dendritic cells, reducing IL-6, IL-1β, IL-23 production through autophagic degradation of MyD88. The combined approach covers several key pathogenic mechanisms of psoriasis.
Conclusion. The combination of taxifolin and andrographolide has high theoretical substantiation for psoriasis therapy due to complementary mechanisms of action on different parts of the inflammatory cascade and potential synergistic effect.
Keywords
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About the authors
Tatyana V. Potupchik
Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky” of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0003-1133-4447
Associate Professor, Department of Pharmacology and Clinical Pharmacology with a Postgraduate Education Course, Candidate of medical sciences
Russian Federation, Partizan Zheleznyak str., 1, Krasnoyarsk, 660022Mikhail A. Ananyan
Advanced Technologies LLC
Email: nanotech@nanotech.ru
ORCID iD: 0009-0007-9019-6981
CEO, Doctor of Technical Sciences, Academician of the Russian Academy of Natural Sciences
Russian Federation, Leninsky Prospekt, 52, sq. 430, Moscow, 119333Mikhail R. Stepanov
Advanced Technologies LLC
Email: stepanson2008@gmail.com
ORCID iD: 0009-0003-0036-0495
Leading Technologist
Russian Federation, Leninsky Prospekt, 52, sq. 430, Moscow, 119333Nikita G. Paskar
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Email: nnikpaskar@yandex.ru
ORCID iD: 0009-0002-6656-6667
SPIN-code: 8269-0440
V year student
Russian Federation, Trubetskaya str., 8/2, 119991, MosсowSofya Y. Khaustova
Synergy University (Moscow University "Synergy")
Email: sofya.khaustova@yandex.ru
ORCID iD: 0009-0001-1768-2170
Senior Lecturer, Department of Internal Medicine
Russian Federation, Leningradsky Prospekt, 80B, bldg. 3, Moscow, 125315References
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