ANALYSIS OF AN EXTEMPORANEOUS FORMULATION FOR THE MANUFACTURE OF SOLUTIONS FOR ELECTROPHORESIS

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Abstract

Introduction: Currently, drug electrophoresis does not lose its relevance and is used for treatment, prevention, and rehabilitation after various diseases. A limited list of drugs is suitable for this procedure, due to the specifics of the impact of physical factors on the molecule of the substance and excipients introduced in the dosage form. Objective: to study and analyze the extemporaneous formulation for the manufacture of solutions for electrophoresis both for the population and for medical organizations using the example of a production pharmacy in Kazan, as well as to conduct a structural analysis of the market for substances used for the extemporaneous manufacture of solutions for electrophoresis. Material and methods: the State Register of Medicinal Products for 2022, invoices of medical organizations and prescriptions from the population received by the production pharmacy for the period from 2017 to 2021 were used as objects of study. The study used the methods of structural analysis, documentary research, content analysis. Results: A range of substances used for the manufacture of solutions for electrophoresis at the federal level was identified, which is represented by 16 INNs under 74 names of pharmaceutical substances, the main share of substances is produced in Russia (70.3%). An analysis of the extemporaneous formulation over the past 5 years has shown that the demand for electrophoresis solutions remains at a consistently high level, which indicates the relevance of the topic under study. Conclusion. As a result of the study, an up-to-date nomenclature list of pharmaceutical solutions for drug electrophoresis was formed.

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About the authors

Kristina Alexandrovna Shubina

Kazan (Privolzhsky) Federal University

Author for correspondence.
Email: shubinakristina.al@mail.ru
PhD student of the Department of Pharmacy at the Institute of Fundamental Medicine and Biology Kazan, Russian Federation

Dilyara Habilevna Shakirova

Kazan (Privolzhsky) Federal University

Email: dhabilevna@mail.ru
Head of the Department of Pharmacy of the Institute of Fundamental Medicine and Biology Kazan, Russian Federation

Rustem Safiullovich Safiullin

Kazan (Privolzhsky) Federal University

Email: safiullinrustem@mail.ru
Professor of the Institute of Fundamental Medicine and Biology, Doctor of Pharmaceutical Sciences. Kazan, Russian Federation

References

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Supplementary files

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1. JATS XML
2. Fig. 1. The share of dosage forms in the individual formulation received from the population for 2017–2021, %

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3. Fig. 2. The share of dosage forms according to the requirements-waybills of medical organizations for 2017–2021, %

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4. Fig. 3. The share of solutions for electrophoresis in the total volume of manufactured liquid dosage forms for 2017–2021, %

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