Design of intranasal dosage forms: biopharmaceutical aspects


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详细

The paper provides an analysis and comparative characteristics of the types of dosage forms of registered intranasal drugs. By using the biopharmaceutical features of the intranasal route of administration, the investigators show the advantages and disadvantages of traditional dosage forms, such as solutions, ointments, lyophilisates, and sprays) and the promising nature of mucoadhesive thermoreversive gels. The current matrix-forming agents (smart polymers and high-molecular-weight compounds) are considered to be promising for designing intranasal gels.

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作者简介

Natalya Demina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: nbd217@mail.ru
professor at the Department of pharmaceutical technology Institute of Pharmacy

Elena Bakhrushina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: bachrauschenh@mail.ru
Associate Professor at the Department of pharmaceutical technology Institute of Pharmacy

Aleksandr Bardakov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: bardakovai@rambler.ru
Associate Professorat the Department of pharmaceutical technology Institute of Pharmacy

Ivan Krasnyuk

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: krasnyuki@mail.ru
head of Department of pharmaceutical technology Institute of Pharmacy

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