Design of capsules with dry corn extract

Introduction. Plant hepatoprotectors are actively used in the therapy of liver diseases. However, the range of medicines of this group, which are made in Russia, is small. Dry corn silk style and stigma extract is a promising hepatoprotective drug. Objective: to develop the composition of dry corn silk style and stigma extract-based capsules and their technology. Material and methods. The investigation object was dry corn silk style and stigma extract. The investigators determined the technological and physicochemical properties of the test extract: fractional composition, flowability, bulk weight, weight loss on drying, damping capacity, and hygroscopicity. Aerosil, lactose, ludipress, and magnesium oxide were used as excipients for capsulation. The experimental capsular masses were assessed by the degree of flowability and hygroscopicity, and the capsules were by the indicators «Disintegration» and «Dissolution». Results. The dry corn silk style and stigma extract has satisfactory flowability, but high hygroscopicity. Improvement in these parameters is favored by the addition of ludipress to the test extract in a ratio of 1:5. The resulting capsules disintegrate within 10 minutes; the dissolution of active ingredients exceeds 95%. Conclusion. Capsules with dry corn silk style and stigma extract can be prepared without prior granulation according to the recipe: dry extract 0.4; ludipress 0.08; size 0 gelatin capsules.

corn silk styles and stigmas, dry extract, capsules, ludipress