The chemical and toxicological properties of nonsteroidal anti-inflammatory drugs and methods for their determination


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详细

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of widely used analgesic, antipyretic, and anti-inflammatory agents in the world, with most of them sold over the counter. In this connection, there is a danger of poisoning from a drug overdose or systematic intake, which can proceed without obvious symptoms. Severe poisonings are characterized by metabolic acidosis, convulsions, coma, acute renal failure, etc. The facts of using the drugs in this group for non-medical purposes make up special cases. NSAIDs vary in chemical structure and therefore differ from each other in the strength and characteristics of action, the frequency and manifestations of side effects. The modification or introduction of new functional groups into medications leads to a decrease or increase in side effects: a positive relationship has been established between lipophilic, brominated compounds and cytotoxicity, while fluorination of the compounds in this group reduces the risk of undesirable effects. To minimize the systemic effect, various dosage forms (cream, gel, and foam for the skin) are brought to the pharmaceutical market. The paper describes modern techniques to identify and quantify the drugs of this group in various biological objects during chemical and toxicological analysis and discusses the possibility of using current methods to establish the fact of using NSAIDs, including those for non-medical purposes. Determination of biomarkers using proteomic technology for the early diagnosis of pathological changes in the systematic administration of NSAIDs is a promising diagnostic area. The structural foundations of the drugs and their classification are presented.

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作者简介

Victor Kutyakov

V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Territorial Forensic Medical Bureau

Email: victor-koutjakov@yandex.ru
Associate Professor of the Department of biological chemistry with courses of medical, pharmaceutical and toxicological chemistry

Ekaterina Kharitonova

V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: ekaterinav1201@gmail.com
Senior Lecturer of the Department of biological chemistry with courses of medical, pharmaceutical and toxicological chemistry

Lyudmila Trufanova

V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: trufanovalv@mail.ru
Professor of the Department of biological chemistry with courses of medical, pharmaceutical and toxicological chemistry

Viktoria Endrzheevskaya-Shurygina

V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: 9135145077@mail.ru
Associate Professor of the Department of biological chemistry with courses of medical, pharmaceutical and toxicological chemistry

Svetlana Pashchenko

V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: psi51@mail.ru
Assistant of the Department of biological chemistry with courses of medical, pharmaceutical and toxicological chemistry

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