Investigation of flavonoids of the herb alfalfa sickle (Medicago falcata L.)
- 作者: Shvets N.N.1, Bubenchikova V.N.1
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隶属关系:
- FSBEI HE KSMU Ministry of Health
- 期: 卷 71, 编号 8 (2022)
- 页面: 15-20
- 栏目: Pharmaceutical chemistry and pharmacognosy
- URL: https://journals.eco-vector.com/0367-3014/article/view/317440
- DOI: https://doi.org/10.29296/25419218-2022-08-02
- ID: 317440
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Introduction. Crescent alfalfa (Medicago falcata L.) is widespread in the regions of central Russia, it is a fodder and honey plant. The plant contains various classes of biologically active substances, among which flavonoids, isoflavonoids are more valuable, because. have different pharmacological efficacy, such as anti-inflammatory, anticarcinogenic, antimicrobial, antioxidant.
In this regard, the identification and qualitative determination of individual flavonoids of the herb sickle alfalfa by various methods is relevant.
Objective: study of the flavonoid compounds of the alfalfa herb by known qualitative reactions, paper chromatography and ultra performance liquid chromatography/MS.
Material and methods. The flavonoid composition of sickle alfalfa was studied using qualitative reactions, paper chromatography, ultra performance liquid chromatography/MS on a Waters Acquility chromatograph with a UV diode array detector and a TQD tandem quadrupole MS detector (Waters) in the gradient elution mode. Flavonoid compounds were extracted with 70% ethyl alcohol.
Results. The flavonoid composition of the crescent alfalfa herb is represented by derivatives of quercetin, myricetin, apigenin, mainly their methoxylated forms. A total of 10 compounds were identified, including 8 flavonols, which were divided into quercetin derivatives (rutin, 4',7-O-Dimethylquercetin-3-O-di-methylglucoside, 4',7-O-dimethylquercetin-3-O-methylglucoside) , the rest are classified as myricetin derivatives. Two compounds are classified as flavones (apigenin-7-O-methylglucoside, apigenin-7-O-acetylglucosyl, glucosylglucoside).
Conclusion. 10 flavonoid compounds, represented mainly by methoxylated compounds, were identified in the herb alfalfa sickle, and therefore it can serve as a potential source of these compounds.
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作者简介
Natalya Shvets
FSBEI HE KSMU Ministry of Health
编辑信件的主要联系方式.
Email: nataliashvetzneo@mail.com
ORCID iD: 0000-0003-4550-781X
postgraduate student of the Department of Pharmacognosy and Botany, Federal State Budgetary Educational Institution of Higher Education "Kursk State Medical University"
St. K. Marx, h. 3, Kursk, Kursk region, 305041, Russian FederationValentina Bubenchikova
FSBEI HE KSMU Ministry of Health
Email: bubenhikova.ksmu@yandex.ru
ORCID iD: 0000-0001-9682-0684
Doctor of Pharmacy, Professor, Head of the Department of Pharmacognosy and Botany, Federal State Budgetary Educational Institution of Higher Education "Kursk State Medical University"
St. K. Marx, h. 3, Kursk, Kursk region, 305041, Russian Federation参考
- Maevsky, P.F. Flora of the middle zone of the European part of Russia: 11th ed. M.: Association of Scientific Publications KMK, 2014; 157–9 (in Russian).
- Wild useful plants of Russia. St. Petersburg: Botan. in-t im. V.L. Komarova RAS: St. Petersburg. state chemical-pharmaceutical acad., 2001; 662 (in Russian).
- Javid T., Adnan M., Tariq A. et al. Antimicrobial activity of three medicinal plants (Artemisia indica, Medicago falcate and Tecoma stans). African J. of Traditional, Complementary and Alternative Medicines. 2015; 12 (3): 91−6. doi: 10.4314/ajtcam.v12i3.11
- Kiselevsky M.V., Babaskina L.I., Babaskin V.S. Study of the cytotoxic activity of extracts of various types of alfalfa. Far Eastern Medical J. 1997; 4: 73–5 (in Russian).
- Kovalev S.V. Chemical study of the lipophilic fraction of sickle alfalfa grass Zaporizhia Medical J. 2013; 3 (78): 94–7 (in Russian).
- Babaskina L.I. Pharmacognostic study of the genera alfalfa, lupine, vetch of the legume family, the prospect of their practical use: author. doctoral dissertations in pharmaceutical sciences. Moscow, 1998; 48 (in Russian).
- Grechana O.V. Aminoacid analysis of raw materials Medicago falcata L. subsp. romanica (Рrodan) O. Schwаrz & Klink. Naukovyy visnyk mizhnarodnogo humanitarnogo universitetu. 2014; 8: 50–2. doi: 10.24959/nphj.14.1942
- Grechana O.V. Pharmacognostic study of yellow alfalfa (crescent or Romanian) Medicago falcata L. subsp. romanica (Рrodan) O. Schwarz & Klink”. Odessa Medical J. 2016; 2 (154): 24–8 (in Russian).
- Grechana O.V. The study of free coumarins in the plant raw material of medicago falcata l. Subsp. Romanica (prodan) O. Schwarz & klink. News of Pharmacy. 2014; 1 (77): 40–3. doi: 10.24959/nphj.14.1942
- Andersen M., Markham K.R. Flavonoids. Chemistry, biochemistry and application: London-New York, 2006; 1198.
- Perova I.B., Eller K.I., Maltseva A.A., Chistyakova A.S., Slivkin A.I., Sorokina A.A. Flavonoids of the herb knotweed. Pharmacy. 2017; 2 (66): 15–9. DOI: https://doi.org/None (in Russian).
- Rodin M.N., Bokov D.O., Samylina I.A. Composition of biologically active compounds of herb succession. Pharmacy. 2022; 2(71):22-26. DOI: https://doi.org/10.29296/25419218-2022-02-04 (in Russian).
- Romanyuk A.A., Moiseev D.V. Hay leaves: component composition, pharmacological properties, standardization. Man and his health. 2021; 2 (24): 53–65. doi: 10.21626/vestnik/2021-2/07 (in Russian).
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