Development and research of tablet form of complex phytosubstance and gliclazide

Introduction. One of the most serious issues of modern medicine is diabetes mellitus, the fight against which, conducted for many years, has not yet brought positive results. Therefore, pharmacotherapy of diabetes mellitus is an acute and significant problem. In this regard, objects of natural origin are of increasing interest, including the possibility of their rational combination with known synthetic agents presented in the form of effective and modern dosage forms.

Purpose of the study. Study of the hypoglycemic activity of the original tablet combination dosage form of gliclazide and a microencapsulated mixture of extracts of galega herb, licorice roots, and mint leaves.

Material and methods. The object of the study were prolonged tablets containing a combination of dry extracts of galega (Galega officinalis L.), licorice (Glycyrrhiza glabra L.), mint (Mentha piperita L.) and gliclazide as active components.

The study of the hypoglycemic activity of the combined tablets was carried out on the model of alloxan type 2 diabetes mellitus. The study was conducted on male Wistar rats weighing 200±10 g. The diabetes mellitus model was established by intraperitoneal administration of alloxan monohydrate, with preliminary administration of nicotinamide solution. Blood glucose concentration from the tail vein of animals was measured using an Accu-Chek Performa Nano glucometer after a single administration of the studied drugs for 24 hours, and on the seventh and fourteenth days against the background of oral administration of glucose.

Results. A comprehensive pharmacological assessment of the effectiveness of the developed combined drug in the form of tablets containing gliclazide and a microencapsulated mixture of galega herb extracts, licorice roots and mint leaves was carried out. The effect of a single administration of the developed drug on the glycemia level of animals with diabetes mellitus was studied. A comparative assessment of resistance to oral glucose administration was carried out against the background of therapy with the studied drug.

Conclusion. The conducted pharmacological studies indicate the presence of a comparable cumulative antidiabetic effect relative to the comparison drug, with a longer maintenance of the physiological level of glycemia. The presence of a comparable level of resistance of the studied drug to oral administration of glucose is confirmed.