Email this article Kinetics of chemical processes in the human brain. Trigger effect and self-stabilization of N-acetylaspartic acid
- Authors: Varfolomeev S.D.1, Semenova N.A.2, Bykov V.I.2, Tsybenova S.B.2
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Affiliations:
- Lomonosov Moscow State University
- Institute of Biochemical Physics of the Russian Academy of Sciences
- Issue: Vol 484, No 4 (2019)
- Pages: 441-446
- Section: Physical chemistry
- URL: https://journals.eco-vector.com/0869-5652/article/view/12555
- DOI: https://doi.org/10.31857/S0869-56524844441-446
- ID: 12555
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Abstract
A kinetic model was proposed for the response of nerve tissue to an external signal stimulus. The model is based on the views of a multistep and non-linear nature of the dynamic variation of the concentrations of N-acetylaspartic acid and N-acetylaspartate in the human nerve tissue. The substrate inhibition effect in this system is a necessary factor for the self-stabilization of N-acetylaspartate as a key brain metabolite. The existence of three stationary states accounts for the trigger behavior of the system.
About the authors
S. D. Varfolomeev
Lomonosov Moscow State University
Author for correspondence.
Email: vibykov@mail.ru
Corresponding Member of the RAS
Russian Federation, 1, Leninskie gory, Moscow, 119991N. A. Semenova
Institute of Biochemical Physics of the Russian Academy of Sciences
Email: vibykov@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991
V. I. Bykov
Institute of Biochemical Physics of the Russian Academy of Sciences
Email: vibykov@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991
S. B. Tsybenova
Institute of Biochemical Physics of the Russian Academy of Sciences
Email: vibykov@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991
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