Gene dunce localization in the polytene chromosome of Drosophila melanogaster long span batch of adjacent chromosomal structures

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  • Authors: Khoroshko V.A.1, Pokholkova G.V.1, Zykova T.Y.1, Osadchiy I.S.2, Zhimulev I.F.1,3
  • Affiliations:
    1. Институт молекулярной и клеточной биологии Сибирского отделения Российской Академии наук
    2. Институт биологии гена Российской Академии наук
    3. Новосибирский национальный исследовательский государственный университет
  • Issue: Vol 484, No 4 (2019)
  • Pages: 507-510
  • Section: Biochemistry, biophysics, molecular biology
  • URL: https://journals.eco-vector.com/0869-5652/article/view/12572
  • DOI: https://doi.org/10.31857/S0869-56524844507-510
  • Cite item

Abstract


The molecular and chromosomal localization of the dunce gene was studied. This gene (167.3 kb) consists almost entirely of introns, in which a cluster of seven short tissue-specific genes is located. On the basis of the results of FISH analysis of the gene fragments, we established that the dunce gene is located within nine chromosomal structures (four bands and five interbands), which contradicts the common idea that genes are located in only one structure (band or interband) or at the boundary of these structures. Our results are quite unexpected and original and greatly expand the current understanding of the genetic organization of interphase chromosomes.


V. A. Khoroshko

Институт молекулярной и клеточной биологии Сибирского отделения Российской Академии наук

Author for correspondence.
Email: vicerna@mcb.nsc.ru

Russian Federation, Новосибирск

G. V. Pokholkova

Институт молекулярной и клеточной биологии Сибирского отделения Российской Академии наук

Email: vicerna@mcb.nsc.ru

Russian Federation, Новосибирск

T. Yu. Zykova

Институт молекулярной и клеточной биологии Сибирского отделения Российской Академии наук

Email: vicerna@mcb.nsc.ru

Russian Federation, Новосибирск

I. S. Osadchiy

Институт биологии гена Российской Академии наук

Email: vicerna@mcb.nsc.ru

Russian Federation, Москва

I. F. Zhimulev

Институт молекулярной и клеточной биологии Сибирского отделения Российской Академии наук; Новосибирский национальный исследовательский государственный университет

Email: vicerna@mcb.nsc.ru

Russian Federation, Новосибирск

Academician of the RAS

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