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Endothelium-dependent hyperpolarization-mediated relaxation pathway in bovine mesenteric lymph nodes
- Authors: Lobov G.I. 1, Dvoretskii D.P. 1
- Affiliations:
- Pavlov Institute of Physiology of the Russian Academy of Sciences
- Issue: Vol 484, No 5 (2019)
- Pages: 645-648
- Section: Physiology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12793
- DOI: https://doi.org/10.31857/S0869-56524845645-648
- Cite item
Abstract
In vitro, endothelium-dependent relaxation mechanisms of smooth muscle cells of the bovine mesenteric lymph node capsule have been studied. The addition of L-NAME and indomethacin to physiological saline inhibited the production of endothelium NO and prostacyclin. In this solution, tetraethylammonium chloride and TRAM-34 increased the tone of the precontracted lymph nodes. Thus, in bovine mesenteric lymph nodes there is an relaxation mechanism mediated by endothelial hyperpolarization, realized by activating Ca2+-dependent K+-channels of large- and intermediate conductance.
About the authors
G. I. Lobov
Pavlov Institute of Physiology of the Russian Academy of Sciences
Author for correspondence.
Email: gilobov@yandex.ru
Russian Federation, Saint-Petersburg
D. P. Dvoretskii
Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: gilobov@yandex.ru
Russian Federation, Saint-Petersburg
Corresponding Member of the RAS
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