Email this article Loading rate of exogenous and autoantigenic determinants on major histocompatibility complex class ii mediates resistance to multiple sclerosis
- Authors: Mamedov A.E.1, Zakharova M.Y.1,2, Favorova O.O.2, Kulakova O.G.2, Boyko A.N.2, Knorre V.D.1, Vorobieva N.A.3, Khurs E.N.4, Kiselev I.C.2, Baulina N.M.2, Gabibov A.G.1,4, Belogurov, Jr. A.A.1,4
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Affiliations:
- Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- The Russian National Research Medical University named after N.I. Pirogov
- Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
- Lomonosov Moscow State University
- Issue: Vol 485, No 2 (2019)
- Pages: 238-241
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12860
- DOI: https://doi.org/10.31857/S0869-56524852238-241
- ID: 12860
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Abstract
Genetic analysis of thousands of patients with multiple sclerosis (MS) and healthy Russian donors showed that the carriage of groups of HLA-DRB1*15 and HLA-DRB1*03 alleles is associated with the risk of MS, whereas the carriage of groups of HLA-DRB1*01 and HLA-DRB1*11 alleles is protective. Recombinant HLA-DRB1*01:01 with a high affinity can recognize the fragments of myelin basic protein (MBP), one of the autoantigens in MS. However, the comparison of the kinetic parameters of the load of MBP and viral HA peptides on HLA-DRB1*01:01, which is catalyzed by HLA-DM, showed a significantly lower rate of exchange of CLIP for MBP peptides. We assume that the observed protective properties of the group of HLA-DRB1*01 alleles may be directly associated with the ability of HLA-DRB1*01:01 to kinetically distinguish peptides of exogenous and endogenous nature.
About the authors
A. E. Mamedov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Author for correspondence.
Email: bioaz12@gmail.com
Russian Federation, Moscow
M. Y. Zakharova
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences;The Russian National Research Medical University named after N.I. Pirogov
Email: bioaz12@gmail.com
Russian Federation, Moscow;Moscow
O. O. Favorova
The Russian National Research Medical University named after N.I. Pirogov
Email: bioaz12@gmail.com
Russian Federation, Moscow
O. G. Kulakova
The Russian National Research Medical University named after N.I. Pirogov
Email: bioaz12@gmail.com
Russian Federation, Moscow
A. N. Boyko
The Russian National Research Medical University named after N.I. Pirogov
Email: bioaz12@gmail.com
Russian Federation, Moscow
V. D. Knorre
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: vera.knorre@gmail.com
Russian Federation, Moscow
N. A. Vorobieva
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: bioaz12@gmail.com
Russian Federation, Moscow
E. N. Khurs
Lomonosov Moscow State University
Email: bioaz12@gmail.com
Russian Federation, Moscow
I. C. Kiselev
The Russian National Research Medical University named after N.I. Pirogov
Email: bioaz12@gmail.com
Russian Federation, Moscow
N. M. Baulina
The Russian National Research Medical University named after N.I. Pirogov
Email: bioaz12@gmail.com
Russian Federation, Moscow
A. G. Gabibov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences;Lomonosov Moscow State University
Email: bioaz12@gmail.com
academician of the RAS
Russian Federation, Moscow;MoscowA. A. Belogurov, Jr.
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences;Lomonosov Moscow State University
Email: bioaz12@gmail.com
Russian Federation, Moscow;Moscow
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