The generation of the human mab RabD4 specific to the rabies virus glycoprotein and characterization thereof

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Abstract


We generated a novel human neutralizing human mAb RabD4 against rabies virus glycoprotein using in vitro stimulation human peripheral B cells produced from immunized donor. It was revealed that the human mAb RabD4 demonstrated high antigen-binding activity and virus-neutralizing activity in the FAVN test with the CVS-11 rabies virus.


About the authors

Е. N. Ilina

Lomonosov Moscow State University

Author for correspondence.
Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow

E. V. Solopova

All-Russian Scientific Center for Molecular Diagnostics and Treatment

Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow

Т. К. Aliev

Lomonosov Moscow State University

Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow

М. V. Larina

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science

Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow

D. S. Balabashin

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science

Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow

N. Е. Varlamov

All-Russian Scientific Center for Molecular Diagnostics and Treatment

Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow

D. А. Dolgikh

Lomonosov Moscow State University;Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science

Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow;Moscow

P. G. Sveshnikov

All-Russian Scientific Center for Molecular Diagnostics and Treatment

Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow

М. P. Kirpichnikov

Lomonosov Moscow State University;Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science

Email: Ekaterina.iljina.7@yandex.ru

Russian Federation, Moscow;Moscow

academician of the RAS

References

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  3. Ilina E. N., Solopova O. N., Balabashin D. S., Larina M. V., Aliev T. K., Grebennikova T. V., Losich M. A., Zaykova O. N., Sveshnikov P. G., Dolgikh D. A., Kirpi- chnikov M. P. // Russ. J. Bioorg. Chem. 2019. V. 45. P. 1-11.
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