Email this article The generation of the human mab RabD4 specific to the rabies virus glycoprotein and characterization thereof
- Authors: Ilina Е.N.1, Solopova E.V.2, Aliev Т.К.1, Larina М.V.3, Balabashin D.S.3, Varlamov N.Е.2, Dolgikh D.А.1,3, Sveshnikov P.G.2, Kirpichnikov М.P.1,3
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Affiliations:
- Lomonosov Moscow State University
- All-Russian Scientific Center for Molecular Diagnostics and Treatment
- Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science
- Issue: Vol 485, No 3 (2019)
- Pages: 370-373
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12889
- DOI: https://doi.org/10.31857/S0869-56524853370-373
- ID: 12889
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Abstract
We generated a novel human neutralizing human mAb RabD4 against rabies virus glycoprotein using in vitro stimulation human peripheral B cells produced from immunized donor. It was revealed that the human mAb RabD4 demonstrated high antigen-binding activity and virus-neutralizing activity in the FAVN test with the CVS-11 rabies virus.
About the authors
Е. N. Ilina
Lomonosov Moscow State University
Author for correspondence.
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow
E. V. Solopova
All-Russian Scientific Center for Molecular Diagnostics and Treatment
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow
Т. К. Aliev
Lomonosov Moscow State University
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow
М. V. Larina
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow
D. S. Balabashin
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow
N. Е. Varlamov
All-Russian Scientific Center for Molecular Diagnostics and Treatment
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow
D. А. Dolgikh
Lomonosov Moscow State University;Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow;Moscow
P. G. Sveshnikov
All-Russian Scientific Center for Molecular Diagnostics and Treatment
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow
М. P. Kirpichnikov
Lomonosov Moscow State University;Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science
Email: Ekaterina.iljina.7@yandex.ru
academician of the RAS
Russian Federation, Moscow;MoscowReferences
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