Neuroprotective action of amidic neurolipins in models of neurotoxicity on the culture of human neural-like cells SH-SY5Y

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Abstract


It was established that in neurodegeneration models in the human neuron-like cell line SH-SY5Y, amide derivatives of arachidonic and docosahexaenoic acids were inactive in experiments with MPP+ and CoCl2 but protected from H2O2. The protective activity of neurolipins decreased in the series DHA-DA > AA-SER >= AA-GLY > AA-GABA >= AA-EA and was manifested starting from a concentration of 0.5 nM.


About the authors

M. G. Akimov

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Author for correspondence.
Email: akimovmike@gmail.com

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

A. M. Ashba

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: akimovmike@gmail.com

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

E. V. Fomina-Ageeva

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: akimovmike@gmail.com

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

N. M. Gretskaya

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: akimovmike@gmail.com

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

N. F. Myasoedov

Institute of Molecular Genetics of the Russian Academy of Sciences

Email: akimovmike@gmail.com

Russian Federation, 2, Kurchatov square, Moscow, 123182

Academician of the Russian Academy of Sciences

V. V. Bezuglov

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: akimovmike@gmail.com

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

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