Email this article Neuroprotective action of amidic neurolipins in models of neurotoxicity on the culture of human neural-like cells SH-SY5Y
- Authors: Akimov M.G.1, Ashba A.M.1, Fomina-Ageeva E.V.1, Gretskaya N.M.1, Myasoedov N.F.2, Bezuglov V.V.1
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Affiliations:
- Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Institute of Molecular Genetics of the Russian Academy of Sciences
- Issue: Vol 485, No 5 (2019)
- Pages: 625-628
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/14319
- DOI: https://doi.org/10.31857/S0869-56524855625-628
- ID: 14319
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Abstract
It was established that in neurodegeneration models in the human neuron-like cell line SH-SY5Y, amide derivatives of arachidonic and docosahexaenoic acids were inactive in experiments with MPP+ and CoCl2 but protected from H2O2. The protective activity of neurolipins decreased in the series DHA-DA > AA-SER >= AA-GLY > AA-GABA >= AA-EA and was manifested starting from a concentration of 0.5 nM.
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About the authors
M. G. Akimov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Author for correspondence.
Email: akimovmike@gmail.com
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
A. M. Ashba
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: akimovmike@gmail.com
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
E. V. Fomina-Ageeva
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: akimovmike@gmail.com
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
N. M. Gretskaya
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: akimovmike@gmail.com
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
N. F. Myasoedov
Institute of Molecular Genetics of the Russian Academy of Sciences
Email: akimovmike@gmail.com
Academician of the Russian Academy of Sciences
Russian Federation, 2, Kurchatov square, Moscow, 123182V. V. Bezuglov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: akimovmike@gmail.com
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
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