Reactivity of 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and reference drugs in model NO-generating systems

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Abstract


The ability of the 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine (I) compound to generate nitrite ions (NO2) and nitrogen monoxide (NO) in model systems with cysteine (Cys) and deoxyhemoglobin (Hb) has been studied. It has been established that there is a more efficient release NO2 and NO from compound I than from Nicorandil. The accumulation rate is 1.5 times higher in the system of Cys with I than with Nitroglycerin. It is shown that, unlike Nitroglycerin, compound I is not reduced by Hb.


About the authors

O. V. Pokidova

Institute of Problem of Chemical Physics of the Russian Academy of Science

Author for correspondence.
Email: pov@icp.ac.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

E. V. Batova

Ivanovo State University

Email: pov@icp.ac.ru

Russian Federation, 39, Ermaka street, Ivanovo, 153025

A. P. Sadkov

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: pov@icp.ac.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

A. B. Eremeev

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: pov@icp.ac.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

B. S. Fedorov

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: pov@icp.ac.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

A. I. Kotelnikov

Institute of Problem of Chemical Physics of the Russian Academy of Science; Lomonosov Moscow State University

Email: pov@icp.ac.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 1, Leninskie gory, Moscow, 119991

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