Email this article Reactivity of 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and reference drugs in model NO-generating systems
- Authors: Pokidova O.V.1, Batova E.V.2, Sadkov A.P.1, Eremeev A.B.1, Fedorov B.S.1, Kotelnikov A.I.1,3
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Affiliations:
- Institute of Problem of Chemical Physics of the Russian Academy of Science
- Ivanovo State University
- Lomonosov Moscow State University
- Issue: Vol 486, No 4 (2019)
- Pages: 437-440
- Section: Chemistry
- URL: https://journals.eco-vector.com/0869-5652/article/view/14466
- DOI: https://doi.org/10.31857/S0869-56524864437-440
- ID: 14466
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Abstract
The ability of the 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine (I) compound to generate nitrite ions (NO2) and nitrogen monoxide (NO) in model systems with cysteine (Cys) and deoxyhemoglobin (Hb) has been studied. It has been established that there is a more efficient release NO2 and NO from compound I than from Nicorandil. The accumulation rate is 1.5 times higher in the system of Cys with I than with Nitroglycerin. It is shown that, unlike Nitroglycerin, compound I is not reduced by Hb.
About the authors
O. V. Pokidova
Institute of Problem of Chemical Physics of the Russian Academy of Science
Author for correspondence.
Email: pov@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
E. V. Batova
Ivanovo State University
Email: pov@icp.ac.ru
Russian Federation, 39, Ermaka street, Ivanovo, 153025
A. P. Sadkov
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: pov@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
A. B. Eremeev
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: pov@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
B. S. Fedorov
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: pov@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
A. I. Kotelnikov
Institute of Problem of Chemical Physics of the Russian Academy of Science; Lomonosov Moscow State University
Email: pov@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 1, Leninskie gory, Moscow, 119991
References
- Wang P.G., Cai T.B. Taniguchi N. Nitric Oxide Donors: for Pharmaceutical and Biological Applications. Weinheim: Wiley-VCH Verlag, 2005. 360 p.
- Page N.A., Fung H.L. // J. Pharm. Sci. 2013. V. 102. № 9. P. 3070-3081.
- Ignarro L.J. Nitric Oxide Biology and Pathobiology. San Diego.: Acad. Press, 2000. 1003 p.
- RU Pat. 2250210 2010.
- Неганова М.Е., Клочкова С.Г., Шевцова Е.Ф., Богатыренко Т.Н., Мищенко Д.В. // БЭБиМ. 2018. T. 166. № 7. P. 53-57.
- Татьяненко Л.В., Доброхотова О.В., Варфоломеев В.Н., Фадеев М.А., Федоров Б.С., Штолько В.Н., Мищенко Д.В. // Хим.-фарм. журн. 2014. T. 48. № 7. С. 3-6.
- Feelisch M. // J. Cardiovasc. Pharmacol. 1991. V. 17. № Suppl. 3. P. S25-S33.
- Yeates R.A., Laufen H., Leitold M. // Mol. Pharmacol. 1985. V. 28. P. 555-559.
- Fox J.B. // Anal. Chem. 1979. V. 51. № 9. P. 1493-1502.
- Huang Z., Shiva S., Kim-Shapiro D.B., Patel R.P. // J. Clin. Invest. 2005. V. 11. № 8. P. 2099-2107.
- Bennett B.M., Nakatsu K., Brein J.F., Marks G.S. // Canad. J. Physiol. Pharmacol. 1984. V. 62. № 6. P. 704-706.
- Antonini E., Brunori M. Hemoglobin and Myoglobin in the Reactions with Ligands, in: North-Holland Research Monographs. Frontiers of Biology. Amsterdam; L., North-Holland Publ., 1971. V. 21. 436 p.
- Geraci G., Parkhurst L.J., Gibson Q.H. // J. Biol. Chem. 1969. V. 244. № . 17. P. 4664-4667.
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