Hypothermia induces postrepolarization refractoriness in the atrial myocardium of the hibernating and active ground squirrel Citellus undulatus
- Authors: Kuzmin V.S.1,2, Abramov A.A.3, Egorov J.V.3, Rosenshtraukh L.V.3
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Affiliations:
- Lomonosov Moscow State University
- N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare Russian Federation
- Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Ministry of Healthcare Russian Federation
- Issue: Vol 486, No 5 (2019)
- Pages: 631-637
- Section: Physiology
- URL: https://journals.eco-vector.com/0869-5652/article/view/14509
- DOI: https://doi.org/10.31857/S0869-56524865631-637
- ID: 14509
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Abstract
The heart of the hibernating mammals demonstrates tolerance to the cold-induced arrhythmias and the electrophysiological mechanisms that underlie this phenomenon expecially in the atrial myocardium is still not elucidated. This study is aimed to the investigation of the hypothermia-induced changes of the atrial action potentials (AP) and refractoriness of the hibernating ground squirrel Citellus undulatus. APs were recorded with usage of standard sharp-electrode technique in the isolated, perfused multicellular continuously paced atrial myocardium preparations obtained from hibernating (HS) and summer active (SAS) squirrels. Action potentials duration (APD) and refractoriness duration (RD) were estimated at 37-17 °С and at various pacing cycle length (200-500 ms). It has been demonstrated that hypothermia causes prolongation of both APD and RD similarly in HS and SAS animals. However, the duration of the refractoriness in the atrial myocardium significantly exceeds the duration of the APs during hypothermia (27-17 °C). Revealed phenomenon may be considered as postrepolarization refractoriness (PRR). Proposed hypothermia-induced PRR probably substantially contributes to the insusceptibility of the hibernators to the cold induced arrhythmias by preventing the afterdepolarizations.
About the authors
V. S. Kuzmin
Lomonosov Moscow State University; N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare Russian Federation
Author for correspondence.
Email: ku290381@mail.ru
Russian Federation, 1, Leninskie gory, Moscow, 119991; 1, Ostrovityanova street, Moscow, 117997
A. A. Abramov
Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Ministry of Healthcare Russian Federation
Email: ku290381@mail.ru
Russian Federation, 15a, 3rd Cherepkovskaya street, Moscow, 121552
Ju. V. Egorov
Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Ministry of Healthcare Russian Federation
Email: ku290381@mail.ru
Russian Federation, 15a, 3rd Cherepkovskaya street, Moscow, 121552
L. V. Rosenshtraukh
Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Ministry of Healthcare Russian Federation
Email: ku290381@mail.ru
Academician of the Russian Academy of Sciences
Russian Federation, 15a, 3rd Cherepkovskaya street, Moscow, 121552References
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