Email this article The role of the brain in the regulation of peripheral noradrenaline-producing organs in rats during morphogenesis
- Authors: Murtazina A.R.1, Nikishina Y.O.1, Dil’mukhametova L.K.1, Sapronova A.Y.1, Ugrumov M.V.1
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Affiliations:
- Koltzov Institute of Developmental Biology Russian Academy of Science
- Issue: Vol 486, No 6 (2019)
- Pages: 748-752
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/14527
- DOI: https://doi.org/10.31857/S0869-56524866748-752
- ID: 14527
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Abstract
This work represents one part of our research project, in which we try to prove, that in the perinatal period exist a humoral regulation between noradrenaline producing organs. In this study we used a rat model that allowed blocking synthesis of noradrenalin in the brain and evaluated gene expression and protein levels of noradrenaline key synthesis enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in peripheral noradrenaline producing organs. As a result we showed increased gene expression of TH and DBH in adrenal glands. This data indicate that if neonatal rat brain lacks an ability to produce noradrenaline, then as a compensatory process synthesis of noradrenaline increased in adrenal glands, so that the concentration levels in blood are kept at normal levels. This indicates that there is a humoral regulation between brain and adrenal glands which is not fully understood yet.
About the authors
A. R. Murtazina
Koltzov Institute of Developmental Biology Russian Academy of Science
Email: zubova.y@gmail.com
Russian Federation, 26,Vavilova street, Moscow, 119334
Yu. O. Nikishina
Koltzov Institute of Developmental Biology Russian Academy of Science
Author for correspondence.
Email: zubova.y@gmail.com
Russian Federation, 26,Vavilova street, Moscow, 119334
L. K. Dil’mukhametova
Koltzov Institute of Developmental Biology Russian Academy of Science
Email: zubova.y@gmail.com
Russian Federation, 26,Vavilova street, Moscow, 119334
A. Ya. Sapronova
Koltzov Institute of Developmental Biology Russian Academy of Science
Email: zubova.y@gmail.com
Russian Federation, 26,Vavilova street, Moscow, 119334
M. V. Ugrumov
Koltzov Institute of Developmental Biology Russian Academy of Science
Email: zubova.y@gmail.com
Academician of the Russian Academy of Sciences
Russian Federation, 26,Vavilova street, Moscow, 119334References
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