Encapsulation of neurotoxins - blockers of nicotinic acetylcholine receptors - in nanomaterials based on sulfated polysaccharides

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Abstract


The three-finger snake neurotoxins are selective antagonists of some nicotinic cholinergic receptor subtypes and are used to study these receptors. The peptide neurotoxin azemiopsin, recently isolated from the venom of Azemipos feae, is a selective muscle-type cholinergic receptor blocker. In order to reduce their toxicity and increase resistance under physiological conditions, we have encapsulated these toxins into nanomaterials. The study of nanomaterials after interaction with neurotoxins by the methods of transmission electron microscopy and dynamic light scattering revealed an increase in the size of nanoparticles, which indicates the inclusion of neurotoxins in nanomaterials.


About the authors

Trung D. Nguyen

Institute of Applied Materials Science, Vietnam Academy of Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology

Email: yutkin@yandex.ru

Viet Nam, 01A, Thanh Loc 29 Street, Thanh Loc Ward, District 12, Ho Chi Minh City; 18, Hoang Quoc Viet, Cau Giay, Hanoi City

The N. Nguyen

Graduate University of Science and Technology, Vietnam Academy of Science and Technology; Tra Vinh University

Email: yutkin@yandex.ru

Viet Nam, 18, Hoang Quoc Viet, Cau Giay, Hanoi City; 126, Nguyen Thien Thanh St., Tra Vinh Province

Khoa C. Nguyen

Institute of Applied Materials Science, Vietnam Academy of Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology

Email: yutkin@yandex.ru

Viet Nam, 01A, Thanh Loc 29 Street, Thanh Loc Ward, District 12, Ho Chi Minh City; 18, Hoang Quoc Viet, Cau Giay, Hanoi City

Quyen N. Tran

Institute of Applied Materials Science, Vietnam Academy of Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology

Email: yutkin@yandex.ru

Viet Nam, 01A, Thanh Loc 29 Street, Thanh Loc Ward, District 12, Ho Chi Minh City; 18, Hoang Quoc Viet, Cau Giay, Hanoi City

Anh N. Hoang

Institute of Applied Materials Science, Vietnam Academy of Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology

Email: yutkin@yandex.ru

Viet Nam, 01A, Thanh Loc 29 Street, Thanh Loc Ward, District 12, Ho Chi Minh City; 18, Hoang Quoc Viet, Cau Giay, Hanoi City

N. S. Egorova

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: yutkin@yandex.ru

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

V. G. Starkov

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: yutkin@yandex.ru

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

V. I. Tsetlin

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: yutkin@yandex.ru

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

Corresponding Member of the Russian Academy of Sciences

Yu. N. Utkin

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Author for correspondence.
Email: yutkin@yandex.ru

Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997

References

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