Combined irradiation by gamma rays and carbon nuclei increases the C/EBP-β LIP-isoform content in the pituitary gland of rats

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C/EBP-β, a basic leucine zipper transcription factor, has important roles in the regulation of organism’s immune and inflammatory responses. Wistar rats subjected to the combined irradiation were characterized by an increase in the content of C/EBP-β LIP-isoform in the pituitary gland. The obtained data indicate that moderate doses of ionizing radiation to initiate the endoplasmic reticulum stress response and are likely to initiate C/EBP-β-mediated cell death according to the apoptotic scenario. This study also confirms the earlier hypothesis about the alterations of the hypothalamic-pituitary-adrenocortical axis in response to moderate doses of ionizing radiation.

About the authors

I. P. Anokhina

V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology


Russian Federation, 23, Kropotkinskiy, Moscow, 119034

Academician of the Russian Academy of Sciences

P. K. Anokhin

V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology


Russian Federation, 23, Kropotkinskiy, Moscow, 119034

V. S. Kokhan

Institute of Biomedical Problems of the Russian Academy of Sciences

Author for correspondence.

Russian Federation, 76А, Khoroshevskoye shosse, Moscow, 123007


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