Efficiency of penetration of dopamine and serotonin peptide derivatives through the artificial membranes

Cover Page

Abstract


A mass spectrometric method has been developed for determining the content of dopamine and serotonin derivatives, which allows to evaluate the efficiency of their penetration through artificial membranes depending on the structure of their peptide fragment. In this case, the diffusion of dopamine and serotonin derivatives through the membrane occurred as a result of competitive interactions. It was shown which compounds in this mixture more easily penetrate through artificial membranes. It was found that the most promising in terms of overcoming the BBB are Boc-Pro-Srt and Boc-Pro-DOPA.


About the authors

V. P. Shevchenko

Institute of Molecular Genetics of the Russian Academy of Sciences

Email: nagaev@img.ras.ru

Russian Federation, 2, Kurchatov square, Moscow, 123182

L. A. Andreeva

Institute of Molecular Genetics of the Russian Academy of Sciences

Email: nagaev@img.ras.ru

Russian Federation, 2, Kurchatov square, Moscow, 123182

I. Yu. Nagaev

Institute of Molecular Genetics of the Russian Academy of Sciences

Author for correspondence.
Email: nagaev@img.ras.ru

Russian Federation, 2, Kurchatov square, Moscow, 123182

K. V. Shevchenko

Institute of Molecular Genetics of the Russian Academy of Sciences

Email: nagaev@img.ras.ru

Russian Federation, 2, Kurchatov square, Moscow, 123182

N. F. Myasoedov

Institute of Molecular Genetics of the Russian Academy of Sciences

Email: nagaev@img.ras.ru

Russian Federation, 2, Kurchatov square, Moscow, 123182

Academician of the Russian Academy of Sciences

References

  1. Maryanovich A.T., Kormilets D.Yu., Polyanovsky A.D. // J. Psychology and Brain Studies. 2017. V. 1. № 1. P. 1-5.
  2. Lee G., Dallas S., Hong M., et al. //Pharmacol. Rev. 2001. V. 53. № 4. P. 569-596.
  3. Di L., Kerns E.H., Fan K., et al. //Eur. J. Med. Chem. 2003. V. 38. № 3. P. 223-232.
  4. Радченко Е.В., Карпов П.В., Соснин С.Б. и др. “Система прогнозирования фармакокинетических свойств и токсичности лекарственных веществ” //XX Менделеевский съезд по общей и прикладной химии. Екатеринбург. 26-30 сентября 2016 г. С. 432.
  5. Дябина А.С., Радченко Е.В., Палюлин В.А., и др. //ДАН 2016. Т. 470. № 6. С. 720-723.

Statistics

Views

Abstract - 180

PDF (Russian) - 96

PlumX


Copyright (c) 2019 Russian academy of sciences

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies