Email this article Efficiency of penetration of dopamine and serotonin peptide derivatives through the artificial membranes
- Authors: Shevchenko V.P.1, Andreeva L.A.1, Nagaev I.Y.1, Shevchenko K.V.1, Myasoedov N.F.1
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Affiliations:
- Institute of Molecular Genetics of the Russian Academy of Sciences
- Issue: Vol 488, No 6 (2019)
- Pages: 682-684
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/17769
- DOI: https://doi.org/10.31857/S0869-56524886682-684
- ID: 17769
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Abstract
A mass spectrometric method has been developed for determining the content of dopamine and serotonin derivatives, which allows to evaluate the efficiency of their penetration through artificial membranes depending on the structure of their peptide fragment. In this case, the diffusion of dopamine and serotonin derivatives through the membrane occurred as a result of competitive interactions. It was shown which compounds in this mixture more easily penetrate through artificial membranes. It was found that the most promising in terms of overcoming the BBB are Boc-Pro-Srt and Boc-Pro-DOPA.
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About the authors
V. P. Shevchenko
Institute of Molecular Genetics of the Russian Academy of Sciences
Email: nagaev@img.ras.ru
Russian Federation, 2, Kurchatov square, Moscow, 123182
L. A. Andreeva
Institute of Molecular Genetics of the Russian Academy of Sciences
Email: nagaev@img.ras.ru
Russian Federation, 2, Kurchatov square, Moscow, 123182
I. Yu. Nagaev
Institute of Molecular Genetics of the Russian Academy of Sciences
Author for correspondence.
Email: nagaev@img.ras.ru
Russian Federation, 2, Kurchatov square, Moscow, 123182
K. V. Shevchenko
Institute of Molecular Genetics of the Russian Academy of Sciences
Email: nagaev@img.ras.ru
Russian Federation, 2, Kurchatov square, Moscow, 123182
N. F. Myasoedov
Institute of Molecular Genetics of the Russian Academy of Sciences
Email: nagaev@img.ras.ru
Academician of the Russian Academy of Sciences
Russian Federation, 2, Kurchatov square, Moscow, 123182References
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